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Shanghai Chaolan Chemical Technology Center
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Products Intro: |
Product Name:RU-302 CAS:1182129-77-6 Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
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Product Name: | RU-302 | Synonyms: | RU-302;Methanone, [2-[[(3,5-dimethyl-4-isoxazolyl)methyl]thio]phenyl][4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]- | CAS: | 1182129-77-6 | MF: | C24H24F3N3O2S | MW: | 475.53 | EINECS: | | Product Categories: | | Mol File: | 1182129-77-6.mol | ![RU-302 Structure](CAS/20210111/GIF/1182129-77-6.gif) |
| RU-302 Chemical Properties |
Boiling point | 624.0±55.0 °C(Predicted) | density | 1.36±0.1 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMSO : 100 mg/mL (210.29 mM; Need ultrasonic) | form | Solid | pka | 1.52±0.20(Predicted) | color | White to off-white |
| RU-302 Usage And Synthesis |
Biological Activity | RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC50in cell assays, and suppresses lung cancer tumor growth[1]. | References | [1]. Kimani SG, et al. Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity. Sci Rep. 2017 Mar 8;7:43908. |
| RU-302 Preparation Products And Raw materials |
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