| Company Name: |
ShangHai Caerulum Pharma Discovery Co., Ltd.
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| Tel: |
18149758185 18149758185 |
| Email: |
sales-cpd@caerulumpharma.com |
| Products Intro: |
Product Name:RU-302
CAS:1182129-77-6
Purity:98% Package:10mg;100mg;1g;10g;100g;1kg
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| Company Name: |
Shanghai YuanYe Biotechnology Co., Ltd.
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| Tel: |
021-61312847; 18021002903 |
| Email: |
3008007409@qq.com |
| Products Intro: |
Product Name:(2-(((3,5-Dimethylisoxazol-4-yl)methyl)thio)phenyl)(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)methanone
CAS:1182129-77-6
Purity:98% Package:5mg Remarks:S89565
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| Product Name: | RU-302 | | Synonyms: | RU-302;Methanone, [2-[[(3,5-dimethyl-4-isoxazolyl)methyl]thio]phenyl][4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]-;RU-302, 10 mM in DMSO;(2-(((3,5-Dimethylisoxazol-4-yl)methyl)thio)phenyl)(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)methanone | | CAS: | 1182129-77-6 | | MF: | C24H24F3N3O2S | | MW: | 475.53 | | EINECS: | | | Product Categories: | | | Mol File: | 1182129-77-6.mol |  |
| | RU-302 Chemical Properties |
| Boiling point | 624.0±55.0 °C(Predicted) | | density | 1.36±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 100 mg/mL (210.29 mM; Need ultrasonic) | | form | Solid | | pka | 1.52±0.20(Predicted) | | color | White to off-white |
| | RU-302 Usage And Synthesis |
| Uses | RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC50in cell assays, and suppresses lung cancer tumor growth[1]. | | Biological Activity | RU-302 is a pan TAM inhibitor that blocks the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain. RU-302 effectively blocks Gas6-inducible Axl receptor activation with a low micromolar IC50in cell assays, and suppresses lung cancer tumor growth[1]. | | IC 50 | Axl | | References | [1]. Kimani SG, et al. Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity. Sci Rep. 2017 Mar 8;7:43908. |
| | RU-302 Preparation Products And Raw materials |
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