MALAT1 inhibitor 5
(Malat1 inhibitor 5) manufacturers
- MALAT1-IN-1
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- $39.00 / 5mg
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2024-11-19
- CAS:827327-28-6
- Min. Order:
- Purity: 99.58%
- Supply Ability: 10g
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| | MALAT1 inhibitor 5
(Malat1 inhibitor 5) Basic information |
| Product Name: | MALAT1 inhibitor 5
(Malat1 inhibitor 5) | | Synonyms: | MALAT1 inhibitor 5
(Malat1 inhibitor 5);TC SL C5;MALAT1 inhibitor 1;1H-Imidazol-2-amine, 5-(4-methoxyphenyl)-N-[(3-methoxyphenyl)methyl]-1-methyl-;MALAT1 inhibitor 5;N-(3-Methoxybenzyl)-5-(4-methoxyphenyl)-1-methyl-1H-imidazol-2-amine;MALAT1 IN 1,inhibit,MALAT1IN1,Inhibitor,MALAT-1-IN-1;5-(4-methoxyphenyl)-N-[(3-methoxyphenyl)methyl]-1-methyl-1H-imidazol-2-amine | | CAS: | 827327-28-6 | | MF: | C19H21N3O2 | | MW: | 323.39 | | EINECS: | | | Product Categories: | | | Mol File: | 827327-28-6.mol |  |
| | MALAT1 inhibitor 5
(Malat1 inhibitor 5) Chemical Properties |
| Boiling point | 534.0±60.0 °C(Predicted) | | density | 1.14±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 125 mg/mL (386.53 mM) | | pka | 7.50±0.25(Predicted) | | form | Solid | | color | Light yellow to khaki |
| | MALAT1 inhibitor 5
(Malat1 inhibitor 5) Usage And Synthesis |
| Uses | MALAT1-IN-1 (compounds 5) is a potent and specific Malat1 (Metastasis-associated lung adenocarcinoma transcript 1) inhibitor. MALAT1-IN-1 modulated Malat1 downstream genes in a dose-dependent manner without affecting expression of nuclear enriched abundant transcript 1 (Neat1) [1]. | | Biological Activity | MALAT1-IN-5 reduces the long noncoding (lnc) RNA metastasis-associated lung adenocarcinoma transcript 1 (Malat1) level (by 54% in 7 days at 1 μM; MMTV-PyMT tumors organoids) via specific interaction with Malat1 triple-helical configuration of 3μ-terminal element for nuclear expression (ENE KD = 2.9 μM under physiologic ionic conditions), but not the homologous 3μ-end triple-helix of Neat1 (MENβ) lncRNA. MALAT1-IN-5 decreases MMTV-PyMT organoid branching morphogenesis (by 38% in 7 days at 1 μM) and modulates the levels of Malat1-targeted mRNAs Krt16 & Csn2. | | storage | Store at -20°C | | References | [1] Abulwerdi FA, et al. Selective Small-Molecule Targeting of a Triple Helix Encoded by the Long Noncoding RNA, MALAT1. ACS Chem Biol. 2019 Feb 15;14(2):223-235. DOI:10.1021/acschembio.8b00807 |
| | MALAT1 inhibitor 5
(Malat1 inhibitor 5) Preparation Products And Raw materials |
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