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BOC Sciences
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1-631-485-4226; 16314854226 |
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| Products Intro: |
Product Name:MRS 1523
CAS:212329-37-8
Purity:98% Remarks:MRS 1523 is a potent and selective adenosine A3 receptor antagonist (Ki= 18.9 nM for human A3R).
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| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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orderCN@merckgroup.com |
| Products Intro: |
Product Name:MRS 1523
CAS:212329-37-8
Purity:>98% (HPLC) Package:25MG Remarks:M1809-25MG
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| | MRS 1523 Basic information |
| Product Name: | MRS 1523 | | Synonyms: | 3-propyl-6-ethyl-5-[(ethylthio)carbonyl]-2 phenyl-4-propyl-3-pyridine carboxylate;UUSHFEVEROROSP-UHFFFAOYSA-N;3-Pyridinecarboxylic acid, 6-ethyl-5-[(ethylthio)carbonyl]-2-phenyl-4-propyl-, propyl ester;MRS 1523 >98% (HPLC) | | CAS: | 212329-37-8 | | MF: | C23H29NO3S | | MW: | 399.55 | | EINECS: | | | Product Categories: | | | Mol File: | 212329-37-8.mol |  |
| | MRS 1523 Chemical Properties |
| Boiling point | 551.3±50.0 °C(Predicted) | | density | 1.100±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: >10 mg/mL | | pka | 1.44±0.28(Predicted) | | form | oil | | color | colorless to light brown |
| | MRS 1523 Usage And Synthesis |
| Description | MRS1523 is a selective adenosine A3 receptor antagonist (Kis = 18.9 and 113 nM for human and rat A3 receptors, respectively, versus Kis = 15.6 and 2.05 μM for rat A1 and A2A receptors, respectively). As activation of the A3 receptor is linked to several second messenger systems for signaling pathways involving inflammatory, asthmatic, and ischemic responses, this selective antagonist may be useful in characterizing the various functions of the receptor. | | Uses | MRS 1523 is a selective A3 adenosine receptor (A3AR) antagonist in human and rat. | | Biochem/physiol Actions | MRS 1523 is a selective?adenosine A3 receptor antagonist in the rat. | | in vitro | mrs1523 reversed the increase in mrna expression in b16-f10 melanoma cells. also, mrs1523 antagonized the modulation in the expression level of the proteins, which indicated that adenosine a3r mediated the responses [1]. | | in vivo | c57bl/6j, male mice, inoculated b16-f10 melanoma cells, were administered mrs1523 at a dose of 100 μg/kg orally twice daily for 15 days. mrs1523 counteracted the activity of ib-meca which is an adenosine a3r agonist. in addition, it was demonstrated that the response was adenosine a3r mediated. the modulation of up-regulation of gsk-3β expression level was neutralized by mrs1523, further suggesting the specificity of the response [1]. | | references | [1]. madi, l., rosenberg-haggen, b., nyska, a., & korenstein, r. enhancing pigmentation via activation of a3 adenosine receptors in b16 melanoma cells and in human skin explants. experimental dermatology. 2012; 22(1): 74-77. |
| | MRS 1523 Preparation Products And Raw materials |
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