106362-32-7
中文名称 | 106362-32-7 |
---|---|
中文同义词 | 多肽T H-ALA-SER-THR-THR-THR-ASN-TYR-THR-OH;肽T;PEPTIDE T;ASTTTNYT |
英文名称 | ALA-SER-THR-THR-THR-ASN-TYR-THR ACETATE |
英文同义词 | ALA-SER-THR-THR-THR-ASN-TYR-THR ACETATE;L-Threonine, L-alanyl-L-seryl-L-threonyl-L-threonyl-L-threonyl-L-asparaginyl-L-tyrosyl-;L-Threonine, N-(N-(N2-(N-(N-(N-(N-L-alanyl-L-seryl)-L-thronyl)-L-threonyl)-L-threonyl)-L-asparaginyl)-L-tyrosyl)-;Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr acetate salt |
CAS号 | 106362-32-7 |
分子式 | C35H55N9O16 |
分子量 | 857.86 |
EINECS号 | |
相关类别 | 目录多肽 |
Mol文件 | 106362-32-7.mol |
结构式 | ![]() |
106362-32-7 性质
沸点 | 1499.5±65.0 °C(Predicted) |
---|---|
密度 | 1.432±0.06 g/cm3(Predicted) |
储存条件 | -20°C |
溶解度 | 溶于二甲基亚砜 |
酸度系数(pKa) | 3.21±0.10(Predicted) |
形态 | 固体 |
颜色 | 白色至米白色 |
CD4, HIV
Peptide T acts to block viral entry as it inhibits in the MAGI cell assay and blocks infection in the luciferase reporter assay using HIV virions pseudotyped with ADA envelope. Peptide T selectively inhibits HIV replication using chemokine receptor CCR5 compared to CXC4. Peptide T at 10 -8 M induces IL-10 production by the human Th2 cell line and PBMC. Also peptide T at 10 -9 M concentration significantly inhibits IFN-g production by PBMC.
Peptide T is administered subcutaneously at different doses and phases of the experimental autoimmune encephalomyelitis (EAE) disease, but Peptide T neither prevents nor ameliorates EAE.