Company Name: |
Shanghai Anyinuo Biomedical Technology Co., Ltd.
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Tel: |
021-34625901 |
Email: |
420970979@qq.com |
Products Intro: |
Product Name:(R)-2-(6-(5-Chloro-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1-oxoisoindolin-2-yl)-N-((S)-2-hydroxy-1-(m-tolyl)ethyl)propanamide CAS:2095719-90-5 Purity:>=98% Package:100mg;250mg;500mg;1g;10g;100g;1kg
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ERK1/2 inhibitor 1 manufacturers
- ERK1/2 inhibitor 1
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- $128.00 / 1mg
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2024-11-13
- CAS:2095719-90-5
- Min. Order:
- Purity: 99.09%
- Supply Ability: 10g
- ERK1/2 inhibitor 1
-
- $128.00 / 1mg
-
2024-11-13
- CAS:2095719-90-5
- Min. Order:
- Purity: 99.09%
- Supply Ability: 10g
|
| ERK1/2 inhibitor 1 Basic information |
Product Name: | ERK1/2 inhibitor 1 | Synonyms: | ERK1/2 INHIBITOR 1;2H-Isoindole-2-acetamide, 6-[5-chloro-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-1,3-dihydro-N-[(1S)-2-hydroxy-1-(3-methylphenyl)ethyl]-α-methyl-1-oxo-, (αR)-;ERK-1/2 inhibitor 1,ERK1/2 inhibitor 1;(R)-2-(6-(5-Chloro-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1-oxoisoindolin-2-yl)-N-((S)-2-hydroxy-1-(m-tolyl)ethyl)propanamide | CAS: | 2095719-90-5 | MF: | C29H32ClN5O4 | MW: | 550.06 | EINECS: | | Product Categories: | | Mol File: | 2095719-90-5.mol | |
| ERK1/2 inhibitor 1 Chemical Properties |
density | 1.344±0.06 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMSO : 250 mg/mL (454.50 mM; Need ultrasonic) | pka | 13.73±0.46(Predicted) | form | Solid | color | Off-white to light yellow |
| ERK1/2 inhibitor 1 Usage And Synthesis |
Biological Activity | ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively[1].
ERK1/2 inhibitor 1 (Compound 27) shows excellent antiproliferative potency with IC50s of 4.9 and 7.5 nM in A375 and Colo205 cells, respectively[1]. | References | [1]. Heightman TD, et al. Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J Med Chem. 2018 Jun 14;61(11):4978-4992. |
| ERK1/2 inhibitor 1 Preparation Products And Raw materials |
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