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4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]-

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4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]- Suppliers list
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:Erastin2
CAS:1695533-44-8
Purity:99% Package:$200.9/5mg;$320.9/10mg;$540.9/25mg;$860.9/50mg;$1350.9/100mg;Bulk package Remarks:99%
Company Name: SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD  
Tel: 13816107857
Email: sales@fortunechem-sh.com
Products Intro: Product Name:4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]-
CAS:1695533-44-8
Purity:98.0% Package:1g
Company Name: BOC Sciences  
Tel: 16314854226
Email: info@bocsci.com
Products Intro: Product Name:Erastin2
CAS:1695533-44-8
Purity:98% Package:1G;10G;100G
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Email: info@efebio.com
Products Intro: Product Name:Erastin2
CAS:1695533-44-8
Purity:98% Package:1mg;2mg;5mg
Company Name: Shanghai Chaolan Chemical Technology Center  
Tel: QQ:65489617 15618227136
Email: info@SuperLan-chem.com
Products Intro: Product Name:Erastin2
CAS:1695533-44-8
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]- Basic information
Product Name:4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]-
Synonyms:4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]-;Erastin2;2-((4-(2-(4-Chlorophenoxy)acetyl)piperazin-1-yl)methyl)-3-(4-isopropoxy-[1,1'-biphenyl]-3-yl)quinazolin-4(3H)-one;4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]-
CAS:1695533-44-8
MF:C36H35ClN4O4
MW:623.14
EINECS:
Product Categories:1
Mol File:1695533-44-8.mol
4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]- Structure
4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]- Chemical Properties
Boiling point 807.0±75.0 °C(Predicted)
density 1.26±0.1 g/cm3(Predicted)
storage temp. Store at -20°,Cprotect from light
solubility DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.25 mg/ml; DMSO: 1 mg/ml
form A crystalline solid
pka5.05±0.10(Predicted)
color White to off-white
Safety Information
MSDS Information
4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]- Usage And Synthesis
DescriptionErastin2 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter.1,2 It inhibits glutamate release in CCF-STTG1 cells (IC50 = 0.0035 μM).2 It induces cell death in HAP1 cells when used at a concentration of 5 μM, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 or deferoxamine .1 Erastin2 also induces ferroptotic cell death in HT-1080 cells (EC50 = 0.15 μM), an effect that can be blocked by the reducing agent β-mercaptoethanol (EC50 = >20 μM).3 It increases lipid peroxidation in HT-1080 cells when used at a concentration of 1 μM.
References1. Cao, J.Y., Poddar, A., Magtanong, L., et al. A genome-wide haploid genetic screen identifies regulators of glutathione abundance and ferroptosis sensitivity Cell Rep. 26(6),1544-1556(2019).
2. Dixon, S.J., Patel, D.N., Welsch, M., et al. Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis Elife 3,e02523(2014).
3. Magtanong, L., Ko, P.-J., To, M., et al. Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state Cell Chem. Biol. 26(3),420-432(2019).
4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]- Preparation Products And Raw materials
Tag:4(3H)-Quinazolinone, 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]-(1695533-44-8) Related Product Information