SNAP 94847 (hydrochloride)
中文名称 | SNAP 94847 (hydrochloride) |
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中文同义词 | 化合物SNAP 94847 HYDROCHLORIDE |
英文名称 | SNAP 94847 (hydrochloride) |
英文同义词 | SNAP 94847 HCL;Antidepressant,SNAP-94847,Melanin concentrating hormone receptor 1,anxiety,inhibit,anxiolytic,SNAP 94847 hydrochloride,Inhibitor,SNAP 94847,SNAP94847,MCHR1 (GPR24) |
CAS号 | 1781934-47-1 |
分子式 | C29H33ClF2N2O2 |
分子量 | 515.04 |
EINECS号 | |
相关类别 | API |
Mol文件 | 1781934-47-1.mol |
结构式 | ![]() |
SNAP 94847 (hydrochloride) 性质
溶解度 | 在 DMSO 中溶解度为 100 mM,在乙醇中溶解度为 100 mM |
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形态 | 固体 |
颜色 | 白色至浅黄色 |
Ki: 2.2 nM (MCHR1); Kd: 530 pM (MCHR1)
SNAP 94847 hydrochloride (oral gavage; 20 mg/kg; 14 days) shows an exaggerated locomotor response to acute quinpirole [treatment: F(2,19)=11.31, treatment × time: F(34,323) = 4.061], the effect of SNAP 94847 on quinpirole-evoked ambulations over the entire observation period is significant compared to the untreated animals. SNAP 94847 hydrochloride (oral administration; 20 mg/kg; 21 days) in drink water, produces a significant increase in ambulation relative to untreated animals [treatment: F(3,28) = 8.971; treatment × time: F(51,476)=11.50]. shows a marked increase in locomotion is apparent after 40 min in the SNAP 94847-treated group,this effect is significant over 180 min. SNAP 94847 hydrochloride (oral administration; 10 mg/kg), has a good bioavailability (59%), low plasma and blood clearances of 4.2 L/hr/kg and 3.3 L/hr/kg, respectively, and the half-life was shown to be 5.2 h in rats in a PK study.
Animal Model: | Rat |
Dosage: | 20 mg/kg |
Administration: | Oral administration; 20 mg/kg; 14 days |
Result: | Exhibited a exaggerated locomotor response to acute quinpirole. |
Animal Model: | Rat |
Dosage: | 10 mg/kg |
Administration: | Oral administration; 10 mg/kg |
Result: | Exhibited good physicochemical properties in rats. |
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | S0080 | SNAP 94847 (hydrochloride) SNAP94847 hydrochloride | 1781934-47-1 | 5mg | 2596.23元 |
2024/04/30 | S0080 | SNAP 94847 (hydrochloride) SNAP94847 hydrochloride | 1781934-47-1 | 25mg | 7854.21元 |