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Product Name:3,3’-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)
CAS:4322-58-1
Purity:>98% Package:1mg;10mg;50mg;100mg;
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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Product Name:3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)
CAS:4322-58-1
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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Shanghai Yifei Biotechnology Co. , Ltd.
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Product Name:3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)
CAS:4322-58-1
Purity:98% Package:1mg;5mg;10mg
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TargetMol Chemicals Inc.
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Product Name:3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)
CAS:4322-58-1
Purity:0 Package:1mg/RMB 647;5mg/RMB 2480;10mg/RMB 4650
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Cayman Chemical Company
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Product Name:3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)
CAS:4322-58-1
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| | 3,3''-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) Basic information |
| Product Name: | 3,3''-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) | | Synonyms: | 3,3''-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one);-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one);2H-1-Benzopyran-2-one, 3,3'-[(2-chlorophenyl)methylene]bis[4-hydroxy-;3,3′-[(2-chlorophenyl)methylene]bis[4-hydroxy-2H-1-benzopyran-2-one;3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) | | CAS: | 4322-58-1 | | MF: | C25H15ClO6 | | MW: | 446.84 | | EINECS: | | | Product Categories: | | | Mol File: | 4322-58-1.mol |  |
| | 3,3''-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) Chemical Properties |
| Melting point | 198-199 °C | | Boiling point | 703.3±60.0 °C(Predicted) | | density | 1.575±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:7): 0.14 mg/ml | | form | A crystalline solid | | pka | 4.20±1.00(Predicted) |
| | 3,3''-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) Usage And Synthesis |
| Description | 3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) is a non-nucleotide inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; Ki = 50 μM).1,2 It also inhibits urease (IC50 = 84.53 μM for the Jack bean enzyme).3 | | References | 1. Choudhary, M.I., Fatima, N., Khan, K.M., et al. New biscoumarin derivatives-cytotoxicity and enzyme inhibitory activities Bioorg. Med. Chem. 14(23),8066-8072(2006).
2. Onyedibe, K.I., Wang, M., and Sintim, H.O. ENPP1, an old enzyme with new functions, and small molecule inhibitors - A STING in the tale of ENPP1 Molecules 24(22),E4192(2019).
3. Khan, K.M., Iqbal, S., Lodhi, M.A., et al. Biscoumarin: New class of urease inhibitors; economical synthesis and activity Bioorg. Med. Chem. 12(8),1963-1968(2004). |
| | 3,3''-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) Preparation Products And Raw materials |
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