| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
CAS:174630-04-7
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| Company Name: |
Hangzhou Peptidego Biotech Co.,Ltd.
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| Tel: |
0571-87213919 |
| Email: |
eric@peptidego.com |
| Products Intro: |
Product Name:Reversin 121
CAS:174630-04-7
Purity:95% or 98% HPLC Package:1mg；5mg；10mg；50mg；100mg,1g or according to customer's detail requirement.
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| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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| Tel: |
400-9205774 |
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sales@glpbio.cn |
| Products Intro: |
Product Name:Reversin 121
CAS:174630-04-7
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| | REVERSIN 121 Basic information |
| Product Name: | REVERSIN 121 | | Synonyms: | REVERSIN 121;BOC-ASP(OBZL)-LYS(Z)-OTBU;L-Lysine, N-[(1,1-dimethylethoxy)carbonyl]-L-α-aspartyl-N6-[(phenylmethoxy)carbonyl]-, 2-(1,1-dimethylethyl) 1-(phenylmethyl) ester | | CAS: | 174630-04-7 | | MF: | C34H47N3O9 | | MW: | 641.75 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | REVERSIN 121 Chemical Properties |
| Boiling point | 786.8±60.0 °C(Predicted) | | density | 1.163±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | DMSO or ethanol: soluble | | form | powder | | pka | 10.75±0.46(Predicted) | | color | white |
| | REVERSIN 121 Usage And Synthesis |
| Description | Reversin 121 is a hydrophobic peptide chemosensitizer that can reverse P-glycoprotein-mediated multidrug resistance. It binds to the P-glycoprotein multidrug transporter (MDR1) with a Kd value of 77 nM. Reversin 121 modulates P-glycoprotein ATPase activity in Sf9 insect cell membranes expressing human MDR1, plasma membrane vesicles from multidrug-resistant cells, and reconstituted proteoliposomes as well as in a variety of MDR1-expressing intact tumor cells. | | Uses | Reversin 121 has been used to determine the activity of P-glycoprotein in human retinal pigment epithelium. | | General Description | Reversin 121 is an analog of reversin and a dipeptide derivative. | | Biochem/physiol Actions | Peptide chemosensitizer, inhibitor of P-glycoprotein. |
| | REVERSIN 121 Preparation Products And Raw materials |
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