Log in | Join Free | china | japan | germany

TD-165

Request For Quotation
TD-165 Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:TD-165
CAS:2305936-56-3
Purity:98.00% Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；200 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:TD-165
CAS:2305936-56-3
Purity:97% Package:$345.9/5mg;$453.9/10mg;$1025.9/50mg;$1088.9/25mg;$1405.9/100mg;$2460.9/250mg;Bul Remarks:97%
Company Name: Sichuan Wei Keqi Biological Technology Co., Ltd.  
Tel: 028-81700200 18116577057
Email: 3003855609@qq.com
Products Intro: Product Name:TD-165
CAS:2305936-56-3
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；200mg；500mg；1g
Company Name: ShangHai Biochempartner Co.,Ltd  
Tel: 17754423994 17754423994
Email: 2853530910@QQ.com
Products Intro: Product Name:ASLAN003
CAS:2305936-56-3
Purity:98% HPLC LCMS Package:1G;100G
Company Name: Shanghai Chaolan Chemical Technology Center  
Tel: QQ:65489617 15618227136
Email: info@SuperLan-chem.com
Products Intro: Product Name:TD-165
CAS:2305936-56-3
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G,500G
TD-165 Basic information
Product Name:TD-165
Synonyms:TD-165;(2S,4R)-1-((2S)-2-(11-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)undecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS:2305936-56-3
MF:C46H59N7O8S
MW:870.07
EINECS:
Product Categories:
Mol File:Mol File
TD-165 Structure
TD-165 Chemical Properties
Boiling point 1096.3±65.0 °C(Predicted)
density 1.292±0.06 g/cm3(Predicted)
solubility DMSO : 50 mg/mL (57.47 mM; Need ultrasonic)
form Solid
pka10.75±0.40(Predicted)
color White to yellow
Safety Information
MSDS Information
TD-165 Usage And Synthesis
Biological ActivityTD-165 is a PROTAC-based cereblon (CRBN) degrader. TD-165 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group[1]. TD-165 (0-100 nM; 24 hours) shows 50% degradation concentration (DC50) and maximum degradation (Dmax) value of 20.4 nM and 99.6%, respectively[1].TD-165 (0.1-10 μM; 24 hours) leads to a concentration-dependent decrease in the level of CRBN proteins in HEK293T cells[1].
References[1]. Kim K, et al. Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera.Sci Rep. 2019 Dec 23;9(1):19654.
TD-165 Preparation Products And Raw materials
Tag:TD-165(2305936-56-3) Related Product Information
TD-106