| Company Name: |
cjbscvictory
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| Tel: |
13348960310 13348960310 |
| Email: |
3003867561@qq.com |
| Products Intro: |
Product Name:BACE1-IN-4
CAS:2361157-92-6
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；200mg
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:BACE1-IN-4
CAS:2361157-92-6
Purity:0 Package:25mg/RMB 20500;50mg/RMB 27300;100mg/RMB 35500
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| | BACE1-IN-4 Basic information |
| Product Name: | BACE1-IN-4 | | Synonyms: | BACE1-IN-4;BACE-1-IN-4,BACE1 IN 4,BACE1IN4;2-Pyrazinecarboxamide, N-[3-[(5R)-3-amino-5-methyl-9,9-dioxido-2,9-dithia-4-azaspiro[5.5]undec-3-en-5-yl]-4-fluorophenyl]-5-(fluoromethoxy)- | | CAS: | 2361157-92-6 | | MF: | C21H23F2N5O4S2 | | MW: | 511.57 | | EINECS: | | | Product Categories: | | | Mol File: | 2361157-92-6.mol |  |
| | BACE1-IN-4 Chemical Properties |
| density | 1.56±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 8.74±0.70(Predicted) |
| | BACE1-IN-4 Usage And Synthesis |
| Description | BACE1-IN-4 is a potent and highly selective BACE1 inhibitor, with an IC50 of 3.8 nM and a Ki of 1.9 nM, more selective at BACE1 over BACE2. Anti-Alzheimer's disease[1].
IC50: 3.8 nM (BACE1), 2090 nM (BACE2)[1]Ki: 1.9 nM (BACE1), 1740 nM (BACE2)[1] BACE1-IN-4 (Compound 22) is a potent and highly selective BACE1 inhibitor, with an IC50 of 3.8 nM and a Ki of 1.9 nM, more selective at BACE1 over BACE2 (IC50, 2090 nM; Ki, 1740 nM)[1]. | | References | [1]. Fujimoto K, et al. Structure-Based Design of Selective β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2. J Med Chem. 2019 May 23;62(10):5080-5095. |
| | BACE1-IN-4 Preparation Products And Raw materials |
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