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| | DC44SMe Basic information |
| Product Name: | DC44SMe | | Synonyms: | DC44SMe;1H-Indole-2-carboxamide, N-[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-(phosphonooxy)-3H-benz[e]indol-3-yl]carbonyl]-1H-indol-5-yl]-5-[[4-methyl-4-(methyldithio)-1-oxopentyl]amino]- | | CAS: | 1354787-76-0 | | MF: | C38H37ClN5O7PS2 | | MW: | 806.29 | | EINECS: | | | Product Categories: | | | Mol File: | 1354787-76-0.mol |  |
| | DC44SMe Chemical Properties |
| density | 1.529±0.06 g/cm3(Predicted) | | pka | 1.69±0.10(Predicted) |
| | DC44SMe Usage And Synthesis |
| Uses | DC44SMe, a phosphate proagent of cytotoxic DNA alkylator DC44, can be used in the synthesis of antibody-drug conjugate (ADC). DC44SMe exhibits IC50s of 2.0 nM, 2.8 nM, and 1.9 nM for Ramos, Namalwa, and HL60/s cancer cells, respectively. DC44SMe can be used for the targeted treatment of cancer[1]. | | References | [1] Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82. DOI:10.1021/jm201284m |
| | DC44SMe Preparation Products And Raw materials |
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