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3-Isoxazolecarboxamide, N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)-

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3-Isoxazolecarboxamide, N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)- Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
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Products Intro: Product Name:3-Isoxazolecarboxamide, N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)-
CAS:2323027-38-7
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: Nanjing Doge Biomedical Technology Co., Ltd
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Products Intro: Product Name:3-Isoxazolecarboxamide, N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)-
CAS:2323027-38-7
Package:5g;100g;1KG;25KG
Company Name: Nantong HI-FUTURE Biology Co., Ltd.
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Products Intro: Product Name:3-Isoxazolecarboxamide, N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)-
CAS:2323027-38-7
Purity:98%+ HPLC Package:100MG,500MG,1G,5G,10G 50MG
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:Ceapin-A7
CAS:2323027-38-7
Package:1 mg；1 mL * 10mM (in DMSO)；10 mg；100 mg；200 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
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Products Intro: Product Name:Ceapin-A7
CAS:2323027-38-7
Package:$48.9/5mg;$187.9/25mg;$513.9/100mg;Bulk package Remarks:Support customization, Item No.:C420006
3-Isoxazolecarboxamide, N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)- Basic information
Product Name:3-Isoxazolecarboxamide, N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)-
Synonyms:3-Isoxazolecarboxamide, N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)-;Ceapin-A7;N-(1-(2,4-Bis(trifluoromethyl)benzyl)-1H-pyrazol-4-yl)-5-(furan-2-yl)isoxazole-3-carboxamide;UPR,Inhibitor,CeapinA7,stress,unfolded protein response,reticulum,Golgi,endoplasmic,Ceapin-A7,ATF6-alpha,inhibit,Ceapin-A-7,Ceapin A7,trafficking
CAS:2323027-38-7
MF:C20H12F6N4O3
MW:470.32
EINECS:
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Mol File:2323027-38-7.mol
3-Isoxazolecarboxamide, N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)- Structure
3-Isoxazolecarboxamide, N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)- Chemical Properties
storage temp. -20°C
solubility Soluble in DMSO (>25 mg/ml)
form solid
color White
Stability:Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
MSDS Information
3-Isoxazolecarboxamide, N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)- Usage And Synthesis
DescriptionCeapin-A7 (2323027-38-7) is a selective inhibitor (IC50 = 590 nM) of transcription factor ATF6α, one of the three branches of the unfolded protein response.1 It inhibits activation of ATF6α in response to ER stress without inhibiting ER-bound transcription factors ATF6? or SREBP or the IRE1 or PERK branches of the UPR.? Ceapin-A7 also show no toxicity to unstressed cells. It induces neomorphic association of the ER and peroxisomes by directly tethering the cytosolic domain of ATF6a to the peroxisomal transporter ABCD3 without inhibiting its transporter activity.2 See companion activator 10-3973.
storageStore at -20°C
ReferencesGallagher et al. (2016), Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch; eLife 5 e11878 Torres et al. (2019), Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether; eLife 8 e46595
3-Isoxazolecarboxamide, N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)- Preparation Products And Raw materials
Tag:3-Isoxazolecarboxamide, N-[1-[[2,4-bis(trifluoromethyl)phenyl]methyl]-1H-pyrazol-4-yl]-5-(2-furanyl)-(2323027-38-7) Related Product Information
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