化合物SY-640
| 中文名称 | 化合物SY-640 |
|---|---|
| 中文同义词 | 化合物SY-640 |
| 英文名称 | Acetamide, N-(1,3-benzodioxol-5-ylmethyl)-N-methyl- |
| 英文同义词 | Acetamide, N-(1,3-benzodioxol-5-ylmethyl)-N-methyl-;Acetamide,inhibit,acnes,Propionibacterium,Endogenous Metabolite,hepatoprotective,Lipopolysaccharide,SY 640,SY640,Inhibitor,SY-640 |
| CAS号 | 168705-70-2 |
| 分子式 | C11H13NO3 |
| 分子量 | 207.23 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 168705-70-2.mol |
| 结构式 |  |
化合物SY-640 性质
| 熔点 | 103 °C |
|---|---|
| 沸点 | 349.2±21.0 °C(Predicted) |
| 密度 | 1.213±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：100 mg/mL（482.56 mM） |
| 酸度系数(pKa) | -0.58±0.70(Predicted) |
| 形态 | 液体 |
| 颜色 | 浅黄至黄色 |
SY-640 是乙酰胺衍生物，具有有效的保肝作用。SY-640 可减轻痤疮丙酸杆菌和脂多糖诱导的小鼠肝损伤。
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Human Endogenous Metabolite
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SY-640 inhibits the number of liver-infiltrating cells and attenuates the increased expression of leukocyte function-associated antigen-1 on these cells.
SY-640 (Oral; 150 mg/kg; once daily for 7 days) significantly inhibits Propionibacterium acnes and Lipopolysaccharide-induced liver injury, but a single administration is without effect.
SY-640 (p.o.; 150 mg/kg; once daily for three days) significantly increases the liver microsomal cytochrome P-450 content and aminopyrine demethylase activity in mice. The hepatic microsomal aminopyrine demethylase activity is obviously inhibited two hours after oral administration of SY-640.