| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Beauveriolide I
CAS:154491-55-1
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Zhejiang Huida Biotech Co., LTD
|
| Tel: |
0571-89903882 13626641628 |
| Email: |
jiangnan@huidabiotech.com |
| Products Intro: |
Product Name:Beauveriolide I
CAS:154491-55-1
Purity:99% HPLC Package:10mg；100mg；1g；10g；100g
|
| Company Name: |
Zhejiang Huida Biotech Co., LTD
|
| Tel: |
0571-0571-89903882 15990081639 |
| Email: |
sunshixuan@huidabiotech.com |
| Products Intro: |
Product Name:Beauveriolide I
CAS:154491-55-1
Purity:99% HPLC Package:10mg；100mg；1g；10g；100g
|
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| | Beauveriolide I Basic information |
| Product Name: | Beauveriolide I | | Synonyms: | Beauveriolide I;Cyclo[L-alanyl-D-leucyl-(3S,4S)-3-hydroxy-4-methyloctanoyl-L-phenylalanyl] | | CAS: | 154491-55-1 | | MF: | C27H41N3O5 | | MW: | 487.64 | | EINECS: | | | Product Categories: | | | Mol File: | 154491-55-1.mol |  |
| | Beauveriolide I Chemical Properties |
| Melting point | 242-244 °C(Solv: methanol (67-56-1)) | | Boiling point | 777.6±60.0 °C(Predicted) | | density | 1.044±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: soluble | | form | A solid | | pka | 13.12±0.70(Predicted) |
| | Beauveriolide I Usage And Synthesis |
| Definition | ChEBI: Beauveriolide I is a cyclodepsipeptide with formula C27H41N3O5. It was originally isolated from the fungus Beauveria sp. FO-6979 during a screening program for inhibitors of lipid droplet accumulation in murine macrophages. It is an inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT) and effective at reducing atherogenic lesions of the artery and heart in mouse models. It has a role as a geroprotector, a fungal metabolite, an EC 2.3.1.26 (sterol O-acyltransferase) inhibitor, an antiatherogenic agent and an antiatherosclerotic agent. It is a macrocycle and a cyclodepsipeptide. | | Biological Activity | Beauveriolide I is a cyclodepsipeptide that has been found in Beauveria and an inhibitor of lipid droplet formation.1 It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cholesterol synthesis (IC50 = 0.78 μM), in primary mouse peritoneal macrophages.1,2 Beauveriolide I also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50 = 6 μM).2 | | References | 1.Namatame, I., Tomoda, H., Si, S., et al.Beauveriolides, specific inhibitors of lipid droplet formation in mouse macrophages, produced by Beauveria sp. FO-6979J. Antibiot. (Tokyo)52(1)1-6(1999)
2.Namatame, I., Tomoda, H., Ishibashi, S., et al.Antiatherogenic activity of fungal beauveriolides, inhibitors of lipid droplet accumulation in macrophagesProc. Nat. Acad. Sci. USA101(3)737-742(2004) |
| | Beauveriolide I Preparation Products And Raw materials |
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