| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:KDM4-IN-3
CAS:1068515-53-6
Purity:95.00% Package:2mg;5mg;10mg
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| | 1H-Pyrazol-5-ol, 1-(1H-benzimidazol-2-yl)-3-methyl-4-phenyl- Basic information |
| | 1H-Pyrazol-5-ol, 1-(1H-benzimidazol-2-yl)-3-methyl-4-phenyl- Chemical Properties |
| Boiling point | 549.7±52.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | pka | 7.92±0.50(Predicted) | | form | Solid | | color | White to off-white |
| | 1H-Pyrazol-5-ol, 1-(1H-benzimidazol-2-yl)-3-methyl-4-phenyl- Usage And Synthesis |
| Uses | KDM4-IN-3 is a KDM4 inhibitor that exhibits improved potency in biochemical assays, is cell-permeable, and kills prostate cancer cells at low micromolar concentrations. | | References | [1] Carter DM, et al. Enhanced Properties of a Benzimidazole Benzylpyrazole Lysine Demethylase Inhibitor: Mechanism-of-Action, Binding Site Analysis, and Activity in Cellular Models of Prostate Cancer. J Med Chem. 2021 Oct 14;64(19):14266-14282. DOI:10.1021/acs.jmedchem.1c00693 |
| | 1H-Pyrazol-5-ol, 1-(1H-benzimidazol-2-yl)-3-methyl-4-phenyl- Preparation Products And Raw materials |
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