17H,21H,21bH,25H-21a,16a-(Iminomethano)-22,27a-methano-23H-diindolizino[6,7-a:7',6'-j]bispyrano[2',3':6,7]indolo[2,3-d:3',2'-g]carbazole-21,23,30,32-tetrone, 1,4,7c,11,15,15a,16,18,19,26,27,28,28a,29-tetradecahydro-1-hydroxy-4,4,11,11,15,15,29,29-octamethyl-, 14-oxide, (7cS,7dR,15aS,16aS,21aR,21bR,2... Suppliers list
|
Company Name: |
BOC Sciences
|
Tel: |
1-631-485-4226; 16314854226 |
Email: |
info@bocsci.com |
Products Intro: |
Product Name:Stephacidin B CAS:360765-75-9 Purity:>95% by HPLC Remarks:0
|
Company Name: |
ChemeGen 中国
|
Tel: |
18818260767 |
Email: |
sales@chemegen.com |
Products Intro: |
Product Name:Stephacidin B CAS:360765-75-9 Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
Company Name: |
Beijing Biocreative Technology Co., Ltd.
|
Tel: |
15522676233 |
Email: |
3007606172@qq.com |
Products Intro: |
Product Name:Stephacidin B CAS:360765-75-9 Purity:99% HPLC Package:2.0mg; 10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; 500.0mg; 1.0g; 5.0g;
|
Company Name: |
TargetMol Chemicals Inc.
|
Tel: |
4008200310 |
Email: |
marketing@tsbiochem.com |
Products Intro: |
Product Name:Stephacidin B CAS:360765-75-9 Package:2500μg/RMB 11800
|
Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
Tel: |
021-65675885 18964387627 |
Email: |
customer_service@efebio.com |
Products Intro: |
Product Name:Stephacidin B CAS:360765-75-9 Purity:95% Package:2.5mg
|
|
| 17H,21H,21bH,25H-21a,16a-(Iminomethano)-22,27a-methano-23H-diindolizino[6,7-a:7',6'-j]bispyrano[2',3':6,7]indolo[2,3-d:3',2'-g]carbazole-21,23,30,32-tetrone, 1,4,7c,11,15,15a,16,18,19,26,27,28,28a,29-tetradecahydro-1-hydroxy-4,4,11,11,15,15,29,29-octamethyl-, 14-oxide, (7cS,7dR,15aS,16aS,21aR,21bR,2... Basic information |
Product Name: | 17H,21H,21bH,25H-21a,16a-(Iminomethano)-22,27a-methano-23H-diindolizino[6,7-a:7',6'-j]bispyrano[2',3':6,7]indolo[2,3-d:3',2'-g]carbazole-21,23,30,32-tetrone, 1,4,7c,11,15,15a,16,18,19,26,27,28,28a,29-tetradecahydro-1-hydroxy-4,4,11,11,15,15,29,29-octamethyl-, 14-oxide, (7cS,7dR,15aS,16aS,21aR,21bR,2... | Synonyms: | Stephacidin B;17H,21H,21bH,25H-21a,16a-(Iminomethano)-22,27a-methano-23H-diindolizino[6,7-a:7′,6′-j]bispyrano[2′,3′:6,7]indolo[2,3-d:3′,2′-g]carbazole-21,23,30,32-tetrone, 1,4,7c,11,15,15a,16,18,19,26,27,28,28a,29-tetradecahydro-1-hydroxy-4,4,11,11,15,15,29,29-octamethyl-, 14-oxide, (7cS,7dR,15aS,16aS,21aR,21bR,22R,22aR,27aS,28aS)-;17H,21H,21bH,25H-21a,16a-(Iminomethano)-22,27a-methano-23H-diindolizino[6,7-a:7',6'-j]bispyrano[2',3':6,7]indolo[2,3-d:3',2'-g]carbazole-21,23,30,32-tetrone, 1,4,7c,11,15,15a,16,18,19,26,27,28,28a,29-tetradecahydro-1-hydroxy-4,4,11,11,15,15,29,29-octamethyl-, 14-oxide, (7cS,7dR,15aS,16aS,21aR,21bR,2...;(7cS,7dR,15aS,16aS,21aR,21bR,22R,22aR,27aS,28aS)-1,4,7c,11,15,15a,16,18,19,26,27,28,28a,29-tetradecahydro-1-hydroxy-4,4,11,11,15,15,29,29-octamethyl-17H,21H,21bH,25H-21a,16a-(Iminomethano)-22,27a-methano-23H-diindolizino[6,7-a:7′,6′-j]bispyrano[2′,3′:6,7]indolo[2,3-d:3′,2′-g]carbazole-21,23,30,32-tetrone, 14-oxide | CAS: | 360765-75-9 | MF: | C52H54N6O8 | MW: | 891.04 | EINECS: | | Product Categories: | | Mol File: | 360765-75-9.mol | |
| 17H,21H,21bH,25H-21a,16a-(Iminomethano)-22,27a-methano-23H-diindolizino[6,7-a:7',6'-j]bispyrano[2',3':6,7]indolo[2,3-d:3',2'-g]carbazole-21,23,30,32-tetrone, 1,4,7c,11,15,15a,16,18,19,26,27,28,28a,29-tetradecahydro-1-hydroxy-4,4,11,11,15,15,29,29-octamethyl-, 14-oxide, (7cS,7dR,15aS,16aS,21aR,21bR,2... Chemical Properties |
density | 1.66±0.1 g/cm3(Predicted) | storage temp. | -20°C | solubility | DMSO: soluble; Methanol: soluble | form | A solid | pka | 12.09±0.70(Predicted) |
| 17H,21H,21bH,25H-21a,16a-(Iminomethano)-22,27a-methano-23H-diindolizino[6,7-a:7',6'-j]bispyrano[2',3':6,7]indolo[2,3-d:3',2'-g]carbazole-21,23,30,32-tetrone, 1,4,7c,11,15,15a,16,18,19,26,27,28,28a,29-tetradecahydro-1-hydroxy-4,4,11,11,15,15,29,29-octamethyl-, 14-oxide, (7cS,7dR,15aS,16aS,21aR,21bR,2... Usage And Synthesis |
Biological Activity | Stephacidin B is a fungal metabolite that has been found in A. ochraceus.1 Dimeric stephacidin B is rapidly converted to a monomer, avrainvillamide , in vitro.2 Stephacidin B is cytotoxic to a variety of cancer cells, including testosterone-independent PC3 and -sensitive LNCaP prostate cancer cells (IC50s = 0.37 and 0.06 μM, respectively) and estradiol-independent SK-BR-3 and -sensitive MCF-7 breast cancer cells (IC50s = 0.32 and 0.27 μM, respectively).1 It induces apoptosis in HepG2 and Huh7 hepatocellular carcinoma cells when used at a concentration of 4 μM.3 | References | 1.Qian-Cutrone, J., Huang, S., Shu, Y.-Z., et al.Stephacidin A and B: Two structurally novel, selective inhibitors of the testosterone-dependent prostate LNCaP cellsJ. Am. Chem. Soc.124(49)14556-14557(2002)
2.Wulff, J.E., Herzon, S.B., Siegrist, R., et al.Evidence for the rapid conversion of stephacidin B into the electrophilic monomer avrainvillamide in cell cultureJ. Am. Chem. Soc.129(16)4898-4899(2007)
3.Hu, L., Zhang, T., Liu, D., et al.Notoamide-type alkaloid induced apoptosis and autophagy via a P38/JNK signaling pathway in hepatocellular carcinoma cellsRSC Adv.9(34)19855-19868(2019) |
| 17H,21H,21bH,25H-21a,16a-(Iminomethano)-22,27a-methano-23H-diindolizino[6,7-a:7',6'-j]bispyrano[2',3':6,7]indolo[2,3-d:3',2'-g]carbazole-21,23,30,32-tetrone, 1,4,7c,11,15,15a,16,18,19,26,27,28,28a,29-tetradecahydro-1-hydroxy-4,4,11,11,15,15,29,29-octamethyl-, 14-oxide, (7cS,7dR,15aS,16aS,21aR,21bR,2... Preparation Products And Raw materials |
|