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BOC Sciences
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1-631-485-4226; 16314854226 |
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info@bocsci.com |
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Product Name:Monascuspiloin CAS:1011244-19-1 Purity:>=95% by HPLC Remarks:0
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Company Name: |
ChemeGen 中国
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18818260767 |
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sales@chemegen.com |
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Product Name:Monascuspiloin CAS:1011244-19-1 Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627 |
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customer_service@efebio.com |
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Product Name:Monascuspiloin CAS:1011244-19-1 Purity:95% Package:100μg;500μg
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TargetMol Chemicals Inc.
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15002134094 |
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marketing@targetmol.cn |
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Product Name:Monascuspiloin CAS:1011244-19-1 Purity:详情请点击官网 Package:1 mg
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Company Name: |
Cayman Chemical Company
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(800) 364-9897 |
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cayman@caymanchem.com |
Products Intro: |
Product Name:Monascuspiloin CAS:1011244-19-1
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| 2H-Furo[3,2-g][2]benzopyran-2,9(3H)-dione, 3a,4,8,9a-tetrahydro-3-(1-hydroxyhexyl)-9a-methyl-6-(1E)-1-propen-1-yl-, (3S,3aR,9aR)- Basic information |
Product Name: | 2H-Furo[3,2-g][2]benzopyran-2,9(3H)-dione, 3a,4,8,9a-tetrahydro-3-(1-hydroxyhexyl)-9a-methyl-6-(1E)-1-propen-1-yl-, (3S,3aR,9aR)- | Synonyms: | 2H-Furo[3,2-g][2]benzopyran-2,9(3H)-dione, 3a,4,8,9a-tetrahydro-3-(1-hydroxyhexyl)-9a-methyl-6-(1E)-1-propen-1-yl-, (3S,3aR,9aR)-;Monascuspiloin;Monascinol | CAS: | 1011244-19-1 | MF: | C21H28O5 | MW: | 360.44 | EINECS: | | Product Categories: | | Mol File: | 1011244-19-1.mol | |
| 2H-Furo[3,2-g][2]benzopyran-2,9(3H)-dione, 3a,4,8,9a-tetrahydro-3-(1-hydroxyhexyl)-9a-methyl-6-(1E)-1-propen-1-yl-, (3S,3aR,9aR)- Chemical Properties |
Boiling point | 577.9±50.0 °C(Predicted) | density | 1.19±0.1 g/cm3(Predicted) | storage temp. | -20°C | form | A solid | pka | 14.43±0.20(Predicted) |
| 2H-Furo[3,2-g][2]benzopyran-2,9(3H)-dione, 3a,4,8,9a-tetrahydro-3-(1-hydroxyhexyl)-9a-methyl-6-(1E)-1-propen-1-yl-, (3S,3aR,9aR)- Usage And Synthesis |
Biological Activity | Monascuspiloin is a fungal metabolite that has been found in M. pilosus M93-fermented rice.1 It induces endoplasmic reticulum stress and autophagy in PC3 prostate cancer cells. Monascuspiloin (15-45 μM) decreases viability of PC3 cells and has an additive effect on the reduction in viability of PC3 cells induced by irradiation when used at a concentration of 25 μM. It induces intratumor apoptosis and autophagy and reduces tumor growth in a PC3 mouse xenograft model when administered at doses of 40 and 120 mg/kg.2 | References | 1.Chiu, H.-W., Fang, W.-H., Chen, Y.-L., et al.Monascuspiloin enhances the radiation sensitivity of human prostate cancer cells by stimulating endoplasmic reticulum stress and inducing autophagyPLoS One7(7)e40462(2012)
2.Chen, R.-J., Hung, C.-M., Chen, Y.-L., et al.Monascuspiloin induces apoptosis and autophagic cell death in human prostate cancer cells via the Akt and AMPK signaling pathwaysJ. Agric. Food Chem.60(29)7185-7193(2012) |
| 2H-Furo[3,2-g][2]benzopyran-2,9(3H)-dione, 3a,4,8,9a-tetrahydro-3-(1-hydroxyhexyl)-9a-methyl-6-(1E)-1-propen-1-yl-, (3S,3aR,9aR)- Preparation Products And Raw materials |
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