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PROTAC BRD4 Degrader-10

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PROTAC BRD4 Degrader-10 Suppliers list
Company Name: Shanghai?Medlife?Pharm-Tech?Co.,?Ltd  
Tel: 021-59167510 18117107507
Email: vip@med-life.cn
Products Intro: Product Name:PROTAC BRD4 Degrader-10
CAS:2417370-49-9
Purity:>=99% Package:10mg;5mg;1mg;50mg
PROTAC BRD4 Degrader-10 Basic information
Product Name:PROTAC BRD4 Degrader-10
Synonyms:PROTAC BRD4 Degrader-10
CAS:2417370-49-9
MF:C59H71F2N9O15S4
MW:1312.51
EINECS:
Product Categories:
Mol File:2417370-49-9.mol
PROTAC BRD4 Degrader-10 Structure
PROTAC BRD4 Degrader-10 Chemical Properties
Boiling point 1397.9±65.0 °C(Predicted)
density 1.47±0.1 g/cm3(Predicted)
pka13.54±0.46(Predicted)
form Solid
color Off-white to light yellow
Safety Information
MSDS Information
PROTAC BRD4 Degrader-10 Usage And Synthesis
UsesPROTAC BRD4 Degrader-10 (compound 8b) is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-10 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 1.3 nM and 18 nM, respectively[1].
References[1] Dragovich PS, et, al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64(5):2576-2607. DOI:10.1021/acs.jmedchem.0c01846
PROTAC BRD4 Degrader-10 Preparation Products And Raw materials
Tag:PROTAC BRD4 Degrader-10(2417370-49-9) Related Product Information
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