| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.com |
| Products Intro: |
Product Name:VU6007477
CAS:2220141-46-6
Purity:详情请点击官网 Package:1 mg
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| | VU6007477 Basic information |
| Product Name: | VU6007477 | | Synonyms: | VU6007477;1H-Pyrrolo[2,3-b]pyridine-6-carboxamide, 1-methyl-4-[[6-(1-methyl-1H-pyrazol-4-yl)-3-pyridinyl]methyl]-N-(tetrahydro-2H-pyran-4-yl)- | | CAS: | 2220141-46-6 | | MF: | C24H26N6O2 | | MW: | 430.5 | | EINECS: | | | Product Categories: | | | Mol File: | 2220141-46-6.mol |  |
| | VU6007477 Chemical Properties |
| Boiling point | 711.3±60.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | pka | 12.07±0.20(Predicted) |
| | VU6007477 Usage And Synthesis |
| Description | VU6007477 is a novel M1 PAM. VU6007477 resulted in good rat M1 PAM potency (EC50 = 230 nM, 93% ACh max), minimal M1 agonist activity (agonist EC50 > 10 μM), good CNS penetration (rat braiplasma Kp = 0.28, Kp,uu = 0.32; mouse Kp = 0.16, Kp,uu = 0.18), and no cholinergic adverse events (AEs, e.g., seizures). |
| | VU6007477 Preparation Products And Raw materials |
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