(3S,6R,7S,8S,12Z,15S,16E)-3,7,15-TRIS-{[TERT-BUTYL(DIMETHYL)SILYL]OXY}-4,4,6,8,12,16-HEXAMETHYL-17-(2-METHYL-1,3-THIAZOL-4-YL)-5-OXO-HEPTADECA-12,16-DIENOIC ACID Suppliers list
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Product Name:(3S,6R,7S,8S,12Z,15S,16E)-3,7,15-Tris-{[tert-butyl(diMethyl)silyl]oxy}-4,4,6,8,12,16-hexaMethyl-17-(2-Methyl-1,3-thiazol-4-yl)-5-oxo-heptadeca-12,16-dienoic Acid CAS:193146-63-3 Package:0.25Mg,2.5Mg
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Product Name:(3S,6R,7S,8S,12Z,15S,16E)-3,7,15-TRIS-([TERT-BUTYL(DIMETHYL)SILYL]OXY)-4,4,6,8,12,16-HEXAMETHYL-17-(2-METHYL-1,3-THIAZOL-4-YL)-5-OXO-HEPTADECA-12,16-DIENOIC ACID Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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Product Name:(3S,6R,7S,8S,12Z,15S,16E)-3,7,15-Tris-{[tert-butyl(diMethyl)silyl]oxy}-4,4,6,8,12,16-hexaMethyl-17-(2-Methyl-1,3-thiazol-4-yl)-5-oxo-heptadeca-12,16-dienoic Acid CAS:193146-63-3 Purity:98%
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Product Name:(3S,6R,7S,8S,12Z,15S,16E)-3,7,15-Tris-{[tert-butyl(diMethyl)silyl]oxy}-4,4,6,8,12,16-hexaMethyl-17-(2-Methyl-1,3-thiazol-4-yl)-5-oxo-heptadeca-12,16-dienoic Acid CAS:193146-63-3
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Product Name:(3S,6R,7S,8S,12Z,15S,16E)-3,7,15-Tris-{[tert-butyl(dimethyl)silyl]oxy}-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxo-heptadeca-12,16-dienoic Acid CAS:193146-63-3
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| (3S,6R,7S,8S,12Z,15S,16E)-3,7,15-TRIS-{[TERT-BUTYL(DIMETHYL)SILYL]OXY}-4,4,6,8,12,16-HEXAMETHYL-17-(2-METHYL-1,3-THIAZOL-4-YL)-5-OXO-HEPTADECA-12,16-DIENOIC ACID Basic information |
Product Name: | (3S,6R,7S,8S,12Z,15S,16E)-3,7,15-TRIS-{[TERT-BUTYL(DIMETHYL)SILYL]OXY}-4,4,6,8,12,16-HEXAMETHYL-17-(2-METHYL-1,3-THIAZOL-4-YL)-5-OXO-HEPTADECA-12,16-DIENOIC ACID | Synonyms: | (3S,6R,7S,8S,12Z,15S,16E)-3,7,15-TRIS-{[TERT-BUTYL(DIMETHYL)SILYL]OXY}-4,4,6,8,12,16-HEXAMETHYL-17-(2-METHYL-1,3-THIAZOL-4-YL)-5-OXO-HEPTADECA-12,16-DIENOIC ACID;GWEYNQSYTRXNRT-VPOHWXGHSA-N;12,16-Heptadecadienoic acid, 3,7,15-tris[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4,4,6,8,12,16-hexamethyl-17-(2-methyl-4-thiazolyl)-5-oxo-, (3S,6R,7S,8S,12Z,15S,16E)- | CAS: | 193146-63-3 | MF: | C45H85NO6SSi3 | MW: | 852.48 | EINECS: | | Product Categories: | Chiral Reagents | Mol File: | Mol File | |
| (3S,6R,7S,8S,12Z,15S,16E)-3,7,15-TRIS-{[TERT-BUTYL(DIMETHYL)SILYL]OXY}-4,4,6,8,12,16-HEXAMETHYL-17-(2-METHYL-1,3-THIAZOL-4-YL)-5-OXO-HEPTADECA-12,16-DIENOIC ACID Chemical Properties |
Boiling point | 761.2±60.0 °C(Predicted) | density | 0.979±0.06 g/cm3(Predicted) | solubility | Acetone, Chloroform, Dichloromethane, Ethanol, Ethyl Acetate | form | Foam | pka | 4.05±0.10(Predicted) | color | Off-White |
| (3S,6R,7S,8S,12Z,15S,16E)-3,7,15-TRIS-{[TERT-BUTYL(DIMETHYL)SILYL]OXY}-4,4,6,8,12,16-HEXAMETHYL-17-(2-METHYL-1,3-THIAZOL-4-YL)-5-OXO-HEPTADECA-12,16-DIENOIC ACID Usage And Synthesis |
Chemical Properties | Off-White Sticky Foam | Uses | An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells'' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers. |
| (3S,6R,7S,8S,12Z,15S,16E)-3,7,15-TRIS-{[TERT-BUTYL(DIMETHYL)SILYL]OXY}-4,4,6,8,12,16-HEXAMETHYL-17-(2-METHYL-1,3-THIAZOL-4-YL)-5-OXO-HEPTADECA-12,16-DIENOIC ACID Preparation Products And Raw materials |
Raw materials | 12,16-Heptadecadienal, 3,7,15-tris[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4,4,6,8,12,16-hexamethyl-17-(2-methyl-4-thiazolyl)-5-oxo-, (3S,6R,7S,8S,12Z,15S,16E)--->(3S,6R,7S,8S,12Z,15S,16E)-3,7,15-TRIS-{[TERT-BUTYL(DIMETHYL)SILYL]OXY}-1-HYDROXY-4,4,6,8,12,16-HEXAMETHYL-17-(2-METHYL-1,3-THIAZOL-4-YL)HEPTADECA-12,16-DIEN-5-ONE |
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