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3-Pyridinecarboxamide, 5-(3,4-dichlorophenyl)-N-[(1R,2R)-2-hydroxycyclohexyl]-6-(2,2,2-trifluoroethoxy)-

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3-Pyridinecarboxamide, 5-(3,4-dichlorophenyl)-N-[(1R,2R)-2-hydroxycyclohexyl]-6-(2,2,2-trifluoroethoxy)- Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: CAS:1269826-44-9
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354
Email: support@targetmol.com
Products Intro: Product Name:OSBPL7-IN-1
CAS:1269826-44-9
Package:1 mg；1 mL * 10mM (in DMSO)；10 mg；100 mg；200 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Email: info@efebio.com
Products Intro: Product Name:ABCA1 inducer compound G
CAS:1269826-44-9
Purity:99% Package:5mg;25mg
Company Name: Shanghai Chaolan Chemical Technology Center  
Tel: QQ:65489617 15618227136
Email: info@SuperLan-chem.com
Products Intro: Product Name:OSBPL7-IN-1
CAS:1269826-44-9
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
Company Name: Shanghai SuperLan Chemcial Technique Centre  
Tel: 021-2022843681 15618226720
Email: chaolaichem@foxmail.com
Products Intro: CAS:1269826-44-9
Purity:95% Package:1G,5G,10G,50G,100G,1KG
3-Pyridinecarboxamide, 5-(3,4-dichlorophenyl)-N-[(1R,2R)-2-hydroxycyclohexyl]-6-(2,2,2-trifluoroethoxy)- Basic information
Product Name:3-Pyridinecarboxamide, 5-(3,4-dichlorophenyl)-N-[(1R,2R)-2-hydroxycyclohexyl]-6-(2,2,2-trifluoroethoxy)-
Synonyms:3-Pyridinecarboxamide, 5-(3,4-dichlorophenyl)-N-[(1R,2R)-2-hydroxycyclohexyl]-6-(2,2,2-trifluoroethoxy)-;OSBPL7-IN-1;OSBPL7,orally active,ABCA1,OSBPL7 IN 1,Inhibitor,OSBPL-7-IN-1,OSBPL7IN1,inhibit;ABCA1 inducer compound G
CAS:1269826-44-9
MF:C20H19Cl2F3N2O3
MW:463.28
EINECS:
Product Categories:
Mol File:1269826-44-9.mol
3-Pyridinecarboxamide, 5-(3,4-dichlorophenyl)-N-[(1R,2R)-2-hydroxycyclohexyl]-6-(2,2,2-trifluoroethoxy)- Structure
3-Pyridinecarboxamide, 5-(3,4-dichlorophenyl)-N-[(1R,2R)-2-hydroxycyclohexyl]-6-(2,2,2-trifluoroethoxy)- Chemical Properties
Boiling point 540.9±50.0 °C(Predicted)
density 1.46±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
form Solid
pka5.98±0.40(Predicted)
color White to off-white
Safety Information
MSDS Information
3-Pyridinecarboxamide, 5-(3,4-dichlorophenyl)-N-[(1R,2R)-2-hydroxycyclohexyl]-6-(2,2,2-trifluoroethoxy)- Usage And Synthesis
Biological ActivityOSBPL7-IN-1 is an orally active oxysterol binding protein like 7 (OSBPL7) inhibitor. OSBPL7-IN-1 promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1]. OSBPL7-IN-1 (compound G or Cpd G; 1-10 μM) increase plasma membrane ATP-binding cassette transporter (ABCA1) in cultured human podocytes, and significantly increase ABCA1-dependent cholesterol efflux[1]. OSBPL7-IN-1 (100 mg/kg; oral gavage; daily; for 28 days) treatment normalizes proteinuria and prevents renal function decline in mouse models of proteinuric kidney disease[1].
References[1]. Matthew B Wright, et al. Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease. Nat Commun. 2021 Aug 2;12(1):4662.
3-Pyridinecarboxamide, 5-(3,4-dichlorophenyl)-N-[(1R,2R)-2-hydroxycyclohexyl]-6-(2,2,2-trifluoroethoxy)- Preparation Products And Raw materials
Tag:3-Pyridinecarboxamide, 5-(3,4-dichlorophenyl)-N-[(1R,2R)-2-hydroxycyclohexyl]-6-(2,2,2-trifluoroethoxy)-(1269826-44-9) Related Product Information