| Company Name: |
Beijing Keyi Tongda Technology Development Co., Ltd
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| Tel: |
17743531240 |
| Email: |
kytd20@sina.com |
| Products Intro: |
Product Name:1-Pentyn-3-ol, 1-[1-(2-amino-6-methoxy-4-pyrimidinyl)-1H-pyrrolo[3,2-c]pyridin-6-yl]-3-methyl-, (3S)-
CAS:2735015-60-6
Purity:98% Package:1g 15000
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:TTBK1-IN-1
CAS:2735015-60-6
Purity:95.00% Package:2mg
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:TTBK1-IN-1
CAS:2735015-60-6
Package:2mg/RMB 2180
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| Company Name: |
Chengdu Peter-like Biotechnology Co., Ltd.
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| Tel: |
028-81700200 13308200041 |
| Email: |
2851167782@qq.com |
| Products Intro: |
Product Name:1-Pentyn-3-ol, 1-[1-(2-amino-6-methoxy-4-pyrimidinyl)-1H-pyrrolo[3,2-c]pyridin-6-yl]-3-methyl-, (3S)-
CAS:2735015-60-6
Purity:HPLC>=98% 现货 Package:5mg10mg20mg50mg100mg500mg1g2g等应客户需求包装
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| | 1-Pentyn-3-ol, 1-[1-(2-amino-6-methoxy-4-pyrimidinyl)-1H-pyrrolo[3,2-c]pyridin-6-yl]-3-methyl-, (3S)- Basic information |
| | 1-Pentyn-3-ol, 1-[1-(2-amino-6-methoxy-4-pyrimidinyl)-1H-pyrrolo[3,2-c]pyridin-6-yl]-3-methyl-, (3S)- Chemical Properties |
| Boiling point | 557.8±60.0 °C(Predicted) | | density | 1.27±0.1 g/cm3(Predicted) | | form | Solid | | pka | 12.91±0.29(Predicted) | | color | White to off-white |
| | 1-Pentyn-3-ol, 1-[1-(2-amino-6-methoxy-4-pyrimidinyl)-1H-pyrrolo[3,2-c]pyridin-6-yl]-3-methyl-, (3S)- Usage And Synthesis |
| Uses | TTBK1-IN-1 is a potent, selective and brain-penetrant tau tubulin kinase 1 (TTBK1) inhibitor with an IC50 of 2.7 nM. TTBK1-IN-1 can be used for the research of alzheimer’s disease and related tauopathies[1]. TTBK1-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | in vivo | TTBK1-IN-1 (intraperitoneal?injection; 2.5, 7, 20, 60, and 180 mg/kg; 5 min prior to isoflurane treatment) significantly decreases in vivo tau phosphorylation at disease-relevant sites at 180 mg/kg. And there is a trend indicating a dose-responsive effect on tau phosphorylation levels at Ser 422 (20 mg/kg, 21% decrease and 60 mg/kg, 60% decrease, respectively, in tau phosphorylation at Ser 422 vs vehicle-treated control) in isoflurane-induced hypothermia mice model[1]. | | References | [1] Tamara Halkina, et al. Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo. J Med Chem. 2021 May 13;64(9):6358-6380. DOI:10.1021/acs.jmedchem.1c00382 |
| | 1-Pentyn-3-ol, 1-[1-(2-amino-6-methoxy-4-pyrimidinyl)-1H-pyrrolo[3,2-c]pyridin-6-yl]-3-methyl-, (3S)- Preparation Products And Raw materials |
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