Company Name: |
PharmaBlock Sciences (Nanjing), Inc.
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Tel: |
4000255188 4000255188 |
Email: |
sales@pharmablock.com |
Products Intro: |
Product Name:ARN-6039 CAS:1675206-11-7 Purity:97% Package:1G;5G;10G;100G;250G
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| 1H-Inden-1-one, 2,3-dihydro-6-methoxy-5-(4-morpholinyl)-2-[[3-(trifluoromethyl)-2-pyridinyl]methyl]- Basic information |
| 1H-Inden-1-one, 2,3-dihydro-6-methoxy-5-(4-morpholinyl)-2-[[3-(trifluoromethyl)-2-pyridinyl]methyl]- Chemical Properties |
Boiling point | 561.5±50.0 °C(Predicted) | density | 1.322±0.06 g/cm3(Predicted) | pka | 2.84±0.20(Predicted) |
| 1H-Inden-1-one, 2,3-dihydro-6-methoxy-5-(4-morpholinyl)-2-[[3-(trifluoromethyl)-2-pyridinyl]methyl]- Usage And Synthesis |
Description | ARN-6039 (being developed by Arrien), is a Potent, Orally Available Inverse Agonist of RORgammat for Autoimmune Neuroinflammatory Demyelinating Disease. The activity of ARN-6039 against ROR?t was demonstrated in a ROR?t-activated IL-17A Prom/LUCPorter assay in HEK 293 cells (360 nM) and in IL-17 release from CD4+T cell assays (220 nM). The compound also possesses ideal CNS drug-like criteria, exhibited excellent pharmacokinetics (%F: 37), pharmacodynamics, and correlative PK/PD and ADME characteristics. |
| 1H-Inden-1-one, 2,3-dihydro-6-methoxy-5-(4-morpholinyl)-2-[[3-(trifluoromethyl)-2-pyridinyl]methyl]- Preparation Products And Raw materials |
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