Company Name: |
Shanghai Easy CDMO Co.,Ltd
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Tel: |
021-61734564 |
Email: |
August@easycdmo.com |
Products Intro: |
Product Name:INDEX NAME NOT YET ASSIGNED CAS:2719051-84-8 Purity:98% Package:5g;10g;20g;100g;100kg
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| INDEX NAME NOT YET ASSIGNED Basic information |
| INDEX NAME NOT YET ASSIGNED Chemical Properties |
density | 1.39±0.1 g/cm3(Predicted) | solubility | Soluble to 50 mM in DMSO | pka | 13.52±0.46(Predicted) | form | Solid | color | White to light yellow |
| INDEX NAME NOT YET ASSIGNED Usage And Synthesis |
Biological Activity | SIM1 is a potent and selective trivalent PROTAC? Degrader based on BET bromodomain inhibitors linked to a Von Hippel Lindau (VHL) ligand via branched linkers. SIM1 degrades all BET family proteins with a preference for BRD2 (DC50 values = 0.7 nM, 1.1 nM and 3.3 nM for BRD4, BRD2 and BRD3, respectively). SIM1 degrades BRD2 more significantly and rapidly than BRD3 and BRD4, and degrades BET proteins with a higher potency than a bivalent degrader. SIM1 also decreases protein levels for Myc and HMOX1 and induces apoptosis in prostate cancer cells. | storage | Store at -20°C |
| INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials |
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