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| | YM 44781 Basic information |
| Product Name: | YM 44781 | | Synonyms: | YM 44781;YM44781;YM-44781;Benzamide, N-[2-(3,4-dichlorophenyl)-4-(3,4-dihydro-3-oxospiro[isoquinoline-1(2H),4'-piperidin]-1'-yl)butyl]-4-fluoro-N-methyl- | | CAS: | 173943-29-8 | | MF: | C31H32Cl2FN3O2 | | MW: | 568.51 | | EINECS: | | | Product Categories: | | | Mol File: | 173943-29-8.mol |  |
| | YM 44781 Chemical Properties |
| Boiling point | 765.3±60.0 °C(Predicted) | | density | 1.34±0.1 g/cm3(Predicted) | | pka | 15.75±0.20(Predicted) |
| | YM 44781 Usage And Synthesis |
| Description | YM44781 is a novel non-peptide tachykinin receptor antagonist. YM44781 exhibited high binding affinities at NK(2) (pK(i) = 9.94 +/- 0.03) and NK(1) (pK(i) = 9.09 +/- 0.02) receptors, respectively. _x000D_
YM-44781 did not produce major inhibition of [Sar9,Met(O(2))11]substance P-induced bladder contraction. |
| | YM 44781 Preparation Products And Raw materials |
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