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Product Name:Methoctramine hydrate
CAS:104807-46-7
Purity:98% Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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Sigma-Aldrich
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Product Name:Methoctramine hydrate
CAS:104807-46-7
Purity:>=97% (NMR), solid Package:10MG Remarks:M105-10MG
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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Product Name:Methoctramine
CAS:104807-46-7
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| | methoctramine tetrahydrochloride hemihydrate Basic information |
| Product Name: | methoctramine tetrahydrochloride hemihydrate | | Synonyms: | methoctramine hemihydrate;methoctramine tetrahydrochloride hemihydrate;Methoctramine hemihydrate tetrahydrochloride, N,Nμ-bis[6-[[(2-Methoxyphenyl)methyl]amino]hexyl]-1,8-octane diamine hemihydrate tetrahydrochloride;Methoctramine tetrahydrochloride hydrate;N,N′-bis[6-[[(2-Methoxyphenyl)methyl]amino]hexyl]-1,8-octane diamine tetrahydrochloride hydrate;MethoctraMine hydrate;methoctramine | | CAS: | 104807-46-7 | | MF: | 2C36H62N4O2.4ClH.H2O | | MW: | 1329.68 | | EINECS: | | | Product Categories: | | | Mol File: | 104807-46-7.mol |  |
| | methoctramine tetrahydrochloride hemihydrate Chemical Properties |
| storage temp. | 2-8°C | | solubility | H2O: >20mg/mL | | form | solid | | color | white |
| | methoctramine tetrahydrochloride hemihydrate Usage And Synthesis |
| Uses | Methoctramine is a muscarinic M2 receptor antagonist. | | Uses | Methoctramine hydrate has been used:
- As a muscarinic receptor 2 antogonist.
- As a test molecule to check its effect on premature osteogenic differentiation of HGPS (Hutchinson-Gilford progeria syndrome) iPS (induced pluripotent)-derived mesenchymal stem cells.
| | Definition | ChEBI: A hydrochloride obtained by combining methoctramine with four molar equivalents of hydrochloric acid. | | General Description | Methoctramine (N, N′-bis [6-[[(2-methoxyphenyl)-methyl] hexyl]-1, 8-octane] diamine) is a derivative of polymethylene tetramine. | | Biochem/physiol Actions | Methoctramine is a selective M2 muscarinic receptor antagonist at nM concentrations. At mM concentrations, methoctramine directly inhibits the high affinity GTPase activity of G proteins. In oesophageal muscle, acetylcholine-mediated increase in calcium and arachidonic acid release were reduced by the M2 receptor antagonist, methoctramine. Methoctramine infused bilaterally in the dorsolateral striatum, considerably enhanced memory in cognitively impaired aged rats. Methoctramine plays a vital role in muscarinic receptor classification. |
| | methoctramine tetrahydrochloride hemihydrate Preparation Products And Raw materials |
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