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| | 75607-67-9 Basic information |
| | 75607-67-9 Chemical Properties |
| Boiling point | 864.2±75.0 °C(Predicted) | | density | 2.39±0.1 g/cm3(Predicted) | | pka | 1.86±0.10(Predicted) |
| | 75607-67-9 Usage And Synthesis |
| Definition | ChEBI: Fludarabine phosphate is a purine arabinonucleoside monophosphate having 2-fluoroadenine as the nucleobase. A prodrug, it is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. Once incorporated into DNA, 2-fluoro-ara-ATP functions as a DNA chain terminator. It is used for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to, or whose disease has progressed during, treatment with at least one standard alkylating-agent containing regimenas. It has a role as an antimetabolite, an antineoplastic agent, an immunosuppressive agent, an antiviral agent, a prodrug and a DNA synthesis inhibitor. It is an organofluorine compound, a nucleoside analogue and a purine arabinonucleoside monophosphate. It is functionally related to a 2-fluoroadenine. |
| | 75607-67-9 Preparation Products And Raw materials |
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