| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:10-Nitrooleate-d17
CAS:2749984-40-3
Purity:95% Package:50μg;100μg;500μg
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| Company Name: |
Cayman Chemical Company
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| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:10-Nitrooleate-d17
CAS:2749984-40-3
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| | INDEX NAME NOT YET ASSIGNED Basic information |
| Product Name: | INDEX NAME NOT YET ASSIGNED | | Synonyms: | 10-nitro-9E-octadecenoic-11,11,12,12,13,13,14,14,15,15,16,16,17,17,18,18,18-d17acid | | CAS: | 2749984-40-3 | | MF: | C18H33NO4 | | MW: | 327.47 | | EINECS: | | | Product Categories: | | | Mol File: | 2749984-40-3.mol |  |
| | INDEX NAME NOT YET ASSIGNED Chemical Properties |
| solubility | Ethanol: 1 mg/ml |
| | INDEX NAME NOT YET ASSIGNED Usage And Synthesis |
| Description | 10-Nitrooleate-d17 is intended for use as an internal standard for the quantification of 10-nitrooleate by GC- or LC-MS. Nitrated unsaturated fatty acids, such as 10- and 12-nitrolinoleate (LNO2; ）, cholesteryl nitrolinoleate, and nitrohydroxylinoleate, represent a new class of endogenous lipid-derived signalling molecules. LNO2 isomers serve as potent endogenous ligands for PPARγ and can also decompose or be metabolized to release nitric oxide.1,2,3,4 10-Nitrooleate is one of two regioisomers of nitrooleate, the other being 9-nitrooleate (OA-NO2; used for the mixture of isomers), which are formed by nitration of oleic acid in approximately equal proportions in vivo.5 Peroxynitrite, acidified nitrite, and myeloperoxidase in the presence of H2O2 and nitrite, all mediate the nitration of oleic acid. OA-NO2 is found in human plasma as the free acid and esterified in phospholipids at concentrations of 619 ± 52 nM and 302 ± 369 nM, respectively. OA-NO2 activates PPARγ approximately 7-fold at a concentration of 1 μM and effectively promotes differentiation 3T3-L1 preadipocytes to adipocytes at 3 μM.5 | | References | 1. Lim, D.G., Sweeney, S., Bloodsworth, A., et al. Nitrolinoleate, a nitric oxide-derived mediator of cell function: Synthesis, characterization, and vasomotor activity Proc. Natl. Acad. Sci. USA 99(25),15941-15946(2002).
2. Schopfer, F.J., Lin, Y., Baker, P.R.S., et al. Nitrolinoleic acid: An endogenous peroxisome proliferator-activated receptor γ ligand Proc. Natl. Acad. Sci. USA 102(7),2340-2345(2005).
3. Lima, E.S., Bonini, M.G., Augusto, O., et al. Nitrated lipids decompose to nitric oxide and lipid radicals and cause vasorelaxation Free Radic. Biol. Med. 39(4),532-539(2005).
4. Baker, P.R.S., Schopfer, F.J., Sweeney, S., et al. Red cell membrane and plasma linoleic acid nitration products: Synthesis, clinical identification, and quantitation Proc. Natl. Acad. Sci. USA 101(32),11577-11582(2004).
5. Baker, P.R., Lin, Y., Schopfer, F.J., et al. Fatty acid transduction of nitric oxide signaling. Multiple nitrated unsaturated acid derivatives exist in human blood and urine serve as endogenous peroxisome proliferator-activated receptor ligands J. Biol. Chem. 280(51),42464-42475(2005). |
| | INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials |
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