L-692,429 , CID121879
| 中文名称 | L-692,429 , CID121879 |
|---|---|
| 中文同义词 | 化合物 T11798;化合物 L-692429 |
| 英文名称 | L 692429 |
| 英文同义词 | L 692429;MK 0751;3-amino-3-methyl-N-[(3R)-2-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4,5-dihydro-3H-1-benzazepin-3-yl]butanamide;L-692,429 , CID121879;L692429,L 692429;Butanamide, 3-amino-3-methyl-N-[(3R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-;L-692429 free base |
| CAS号 | 145455-23-8 |
| 分子式 | C29H31N7O2 |
| 分子量 | 509.611 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 145455-23-8.mol |
| 结构式 |  |
L-692,429 , CID121879 性质
| 密度 | 1.33±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：50 mg/ml（98.12 mM） |
| 酸度系数(pKa) | 4.14±0.10(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
Growth hormone secretagogue (GHS)
L-692429 stimulates intracellular calcium release, inositol phosphate (IP) turnover, cAMP-responsive element binding protein (CREB) activity, serum-responsive element activity and bioluminescence resonance energy transfer (BRET) activity with EC
50
values of 26 nM, 47 nM, 60 nM, 63 nM and 58 nM, respectively.
HeLa-T4 cells transiently expressing the flag epitope-tagged growth hormone secretagogue (GHS) receptor are treated with L-692429. The release of intracellular calcium is measured using fluorometry with the calcium indicator dye fluo-3/AM. Untransfected HeLa-T4 cells are unresponsive to L-692429 treatment, whereas HeLa-T4 cells transiently expressing GHS receptors demonstrate an increase in fluorescent emission after L-692429 treatment. A significant increase in luciferase activity after L-692429 treatment is seen, suggesting that activation of the GHS receptor stimulates the MAPK pathway.
When tested in anesthetized rats (Wistar rats), L-756867 inhibits L-692429 (100 μg/kg)-stimulated GH secretion in a dose-dependent manner. Complete inhibition is observed at an i.v. dose of 100 μg/kg of L-756867.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-10957 | L-692429 | 1 mg | 2181元 | |
| 2024/08/19 | HY-10957 | L-692,429 , CID121879 L-692429 | 145455-23-8 | 5mg | 4800元 |