POLYKETOMYCIN
| 中文名称 | POLYKETOMYCIN |
|---|---|
| 中文同义词 | 化合物 T12517;聚酮霉素 |
| 英文名称 | polyketomycin |
| 英文同义词 | polyketomycin;1,3,7,10,12(2H,4H,5H)-Naphthacenepentone, 4-[[(2S,5S,6R)-5-[[2,6-dideoxy-4-O-(2-hydroxy-3,6-dimethylbenzoyl)-3-C-methyl-α-L-xylo-hexopyranosyl]oxy]tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-4a,12a-dihydro-4a,11,12a-trihydroxy-2-(1-hydroxyethylidene)-8-methoxy-6-methyl-, (2E,4S,4aR,12aS)- |
| CAS号 | 200625-47-4 |
| 分子式 | C44H48O18 |
| 分子量 | 864.85 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 200625-47-4.mol |
| 结构式 |  |
POLYKETOMYCIN 性质
| 沸点 | 1032.6±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.54±0.1 g/cm3(Predicted) |
| 酸度系数(pKa) | 3.84±0.70(Predicted) |
Polyketomycin 是一种从链霉菌属中分离的四环醌糖苷抗生素。Polyketomycin 抑制革兰氏阳性细菌 (Gram-positive bacteria) 的生长，其 MIC 值小于 0.2 µg/mL。Polyketomycin 具有抗菌，抗癌，抗疟疾的作用。
|
Traditional Cytotoxic Agents
|
Polyketomycin exhibits growth inhibition against L1210 leukemia, EL-4 leukemia, P388 leukemia, Ehrlich carcinoma, IMC carcinoma, colon 26 adnocarcinoma, Meth A fibrosarcoma, FS-3 fibrosarcoma and B16-BL10 melanoma with IC 50 values of 3.3 μg/mL, 2.1 μg/mL, 5.2 μg/mL, 1 μg/mL, 0.9 μg/mL, 1.8 μg/mL, 2.4 μg/mL, 1.5 μg/mL and 1.6 μg/mL, respectively.
The acute toxicity (LD 50 , ip) of Polyketomycin in mice is estimated to be 6.25-12.5mg/kg.