FK706
| 中文名称 | FK706 |
|---|---|
| 中文同义词 | 化合物 T15285 |
| 英文名称 | FK 706 |
| 英文同义词 | FK 706;FK-706,FK706 |
| CAS号 | 144055-55-0 |
| 分子式 | C26H34F3N4NaO7 |
| 分子量 | 594.56 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 144055-55-0.mol |
| 结构式 |  |
FK706 性质
| 储存条件 | 4°C, protect from light |
|---|---|
| 溶解度 | 二甲基亚砜：115 mg/ml（194.08 mM） |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
IC50: 83 nM (Human neutrophil elastase), 22 nM (Mouse neutrophil elastase) and 100 nM (Porcine pancreatic elastase);
Ki: 4.2 nM (Human neutrophil elastase)
FK706 effectively inhibits the hydrolysis of bovine neck ligament elastin (2 mg/mL final concentration) by human neutrophil elastase (4 μg/mL final concentration) with an
IC50
value of 230 nM.
FK706 blocks the release of inflammatory chemokines, suppresses the expression of IL-8 and MCP-1 mRNA, and suppresses NF-κB activation. It seems possible that FK706 may directly blocks human lung fibroblasts activation of NF-κB, preventing expression of inflammatory chemokines during cigarette smoke–induced lung inflammation.
FK706 (10-100 mg/kg; subcutaneous injection; for 1-6 hours; male C57BL mice) treatment significantly suppresses human neutrophil elastase (20 μg/paw)-induced paw edema in mice in a dose-dependent manner (47% inhibition at a dose of 100 mg/kg).
| Animal Model: | Male C57BL mice (6 weeks old) injected with human neutrophil elastase |
| Dosage: | 10 mg/kg, 32 mg/kg, 100 mg/kg |
| Administration: | Subcutaneous injection; for 1 hour, 2 hours, 4 hours, 6 hours |
| Result: | Significantly suppressed human neutrophil elastase-induced paw edema in mice in a dose-dependent manner. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-19269 | FK706 | 1 mg | 2136元 | |
| 2024/04/30 | HY-19269 | FK706 FK706 | 144055-55-0 | 10mg | 7500元 |