PYR-GLY-PRO-PRO-ILE-SER-ILE-ASP-LEU-SER-LEU-GLU-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-GLU-ARG-ALA-GLU-GLN-LEU-ALA-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THR-ALA-NH2
生物活性靶点体外研究体内研究 用途与合成方法 MSDS PYR-GLY-PRO-PRO-ILE-SER-ILE-ASP-LEU-SER-LEU-GLU-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-GLU-ARG-ALA-GLU-GLN-LEU-ALA-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THR-ALA-NH2价格(试剂级) 上下游产品信息
| 中文名称 | PYR-GLY-PRO-PRO-ILE-SER-ILE-ASP-LEU-SER-LEU-GLU-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-GLU-ARG-ALA-GLU-GLN-LEU-ALA-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THR-ALA-NH2 |
|---|---|
| 中文同义词 | PYR-GLY-PRO-PRO-ILE-SER-ILE-ASP-LEU-SER-LEU-GLU-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-GLU-ARG-ALA-GLU-GLN-LEU-ALA-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THR-ALA-NH2 |
| 英文名称 | Cortagine |
| 英文同义词 | Cortagine;pGlu-Gly-Pro-Pro-Ile-Ser-Ile-Asp-Leu-Ser-Leu-Glu-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Glu-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ala |
| CAS号 | |
| 分子式 | |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | Mol File |
| 结构式 |
PYR-GLY-PRO-PRO-ILE-SER-ILE-ASP-LEU-SER-LEU-GLU-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-GLU-ARG-ALA-GLU-GLN-LEU-ALA-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THR-ALA-NH2 性质
| 形态 | 固体 |
|---|---|
| 颜色 | 白色至米白色 |
PYR-GLY-PRO-PRO-ILE-SER-ILE-ASP-LEU-SER-LEU-GLU-LEU-LEU-ARG-GLU-VAL-LEU-GLU-MET-GLU-ARG-ALA-GLU-GLN-LEU-ALA-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THR-ALA-NH2 用途与合成方法
Cortagine 是一种选择性的促肾上腺皮质激素释放因子受体亚型 1 (CRF1) 激动剂，对 rCRF1 的 IC50 为 2.6 nM。Cortagine 在小鼠模型中具有抗焦虑和抗抑郁作用。
IC50: 2.6 nM (rCRF1)
Cortagine inhibits rCRF1 (EC
50
=0.18 nM) and mCRF
2β
(EC
50
=16 nM) in transfected HEK-293 cells.
Cortagine (30, 100, 300 ng; i.c.v.) significantly decreases the percent time spent in the open arms and number of open arm entries of the elevated plus-maze (EPM) test in nine-week-old male C57BL/6J mice.