PG01
| 中文名称 | PG01 |
|---|---|
| 中文同义词 | 化合物 T16516;N-甲基-N-[2-[[4-(1-甲基乙基)苯 |
| 英文名称 | PHENYLGLYCINE-01 |
| 英文同义词 | PHENYLGLYCINE-01;N-Methyl-N-[2-[[4-(1-Methylethyl)phenyl]amino]-2-1H-indole-3-acetamide;PG 01;2-[(2-1H-indol-3-yl-acetyl)-methylamino]-N-(4-isopropylphenyl)-2-phenylacetamide;N-Methyl-N-[2-[[4-(1-methylethyl)phenyl]amino]-2-oxo-1-phenylethyl]-1H-indole-3-acetamide;1H-Indole-3-acetamide, N-methyl-N-[2-[[4-(1-methylethyl)phenyl]amino]-2-oxo-1-phenylethyl]-;PG-01 >=98% (HPLC);PG-01,PG01 |
| CAS号 | 853138-65-5 |
| 分子式 | C28H29N3O2 |
| 分子量 | 439.55 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 853138-65-5.mol |
| 结构式 |  |
PG01 性质
| 沸点 | 704.6±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.217±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：≥10mg/mL |
| 形态 | 粉末 |
| 酸度系数(pKa) | 13.31±0.70(Predicted) |
| 颜色 | 白色至类白色 |
CFTR
PG01 itself does not activate ∆F508-CFTR, produces substantial ∆F508-CFTR Cl - current after the addition of 0.5 and 2 μM Forskolin. PG01 at 100 nM strongly stimulates channel activity with multiple channel openings observed. The apparent K d for PG01 for G551D-CFTR activation is 1 μM, approximately 100-fold better than that of genistein. The potency for activation G1349D-CFTR by PG01 is even better at 40 nM. PG01 produces large currents in both G551D- and G1349D-CFTR expressing cells. The currents are sensitive to CFTRinh-172 and are not seen in nontransfected cells.
Pharmacokinetic analysis of PG01 in rats is done by serial measurements of plasma concentrations after single bolus infusions (5 mg/kg). PG01 pharmacokinetics fitted a two-compartment model with half-times of ＜5 min and 130 min with volume of distribution 4 L. Microsome metabolism studies and rat pharmacokinetic analysis suggests significantly more rapid metabolism of PG01 than SF-03.
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-103369 | PG01 PG01 | 853138-65-5 | 1mg | 1550元 |
| 2024/04/30 | HY-103369 | PG01 PG01 | 853138-65-5 | 5mg | 4600元 |