| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Email: |
inquiries@lgmpharma.com |
| Products Intro: |
Product Name:OfatuMuMab
CAS:679818-59-8
Purity:Typically NLT 98%
|
| Company Name: |
Dalian Meilun Biotech Co., Ltd.
|
| Tel: |
0411-62910999 13889544652 |
| Email: |
meilunui@163.com |
| Products Intro: |
Product Name:Ofatumumab
CAS:679818-59-8
Purity:>95% Package:5MG
|
|
| | ofatumumab Basic information |
| Product Name: | ofatumumab | | Synonyms: | ofatumumab;Research Grade Ofatumumab(DHC90701);Ofatumumab (anti-CD20) | | CAS: | 679818-59-8 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![ofatumumab Structure]() |
| | ofatumumab Chemical Properties |
| form | Liquid | | color | Colorless to light yellow |
| | ofatumumab Usage And Synthesis |
| Description | Considered as the most common form of leukemia in adults, CLL is
characterized by the accumulation of abnormal B lymphocytes and manifests itself as lymph node enlargement and bone marrow failure in
symptomatic patients.
Ofatumumab
is the second marketed mAb to target CD20. Compared to its predecessor,it is a fully human mAb that was generated via transgenic mouse and
hybridoma technology. In addition to the Fab portion that recognizes
CD20, the Fc domain mediates immune effector functions to lyse cells
via complement-dependent cytotoxicity (CDC) and antibody-dependent,
cell-mediated cytotoxicity (ADCC). Ofatumumab targets a different, discontinuous epitope on CD20 than rituximab; it binds specifically to both
the small and large extracellular loops of the CD20 molecule expressed on
normal B lymphocytes and on B-cell CL, and its binding does not induce
receptor internalization nor shedding from the cell surface. In addition to
targeting a different epitope on CD20, ofatumumab also exhibits a slower
off-rate. These characteristics have been proposed as reasons for its ability
to lyse rituximab-resistant cells that express low levels of CD20 and for its
greater in vitro activity against CLL cells versus rituximab.
The most common adverse events were neutropenia, pneumonia, pyrexia, cough, diarrhea, anemia, fatigue, dyspnea, rash, nausea, bronchitis, and upper respiratory tract infections. | | Originator | Genmab (Denmark) | | Brand name | Arzerra | | Clinical Use | IgG1 monoclonal antibody:
Treatment of chronic lymphocytic leukaemia | | Drug interactions | Potentially hazardous interactions with other drugs
Live vaccines: avoid concomitant use. | | Metabolism | Ofatumumab is eliminated by proteolytic enzymes and
via binding to B-cells. |
| | ofatumumab Preparation Products And Raw materials |
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