| Company Name: |
Riedel-de Haen AG
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| Tel: |
800 558-9160 |
| Email: |
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| Products Intro: |
Purity:affinity isolated antibody, lyophilized powder Remarks:clone 1A11-A9, purified immunoglobulin, buffered aqueous solution
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| Company Name: |
SIGMA-RBI
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| Tel: |
800 736 3690 (Orders) |
| Email: |
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| Products Intro: |
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| | Anti-Ngb Basic information |
| Product Name: | Anti-Ngb | | Synonyms: | Anti-Neuroglobin antibody produced in rabbit;Anti-Ngb;Monoclonal Anti-NGB antibody produced in mouse;Anti-FLJ39774;Anti-GTPBP4 antibody produced in mouse;Anti-CRFG;Anti-GTPBP4 (606-620) antibody produced in rabbit;Anti-GTPBP4 Nucleolar GTP-binding protein 1 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Anti-Ngb Structure]() |
| | Anti-Ngb Chemical Properties |
| storage temp. | −20°C | | form | buffered aqueous solution |
| | Anti-Ngb Usage And Synthesis |
| Uses | Anti-Neuroglobin antibody produced in rabbit has been used in
- immunofluorescence double staining
- immunostaining
- immunohistochemistry
| | General Description | Neuroglobin is an oxygen-binding heme protein predominantly expressed in the nervous system in man and other vertebrates. Neuroglobin belongs to the globin superfamily. It displays the typical globin fold, but it shares little amino acid sequence similarity with vertebrate hemoglobins and myoglobins. Neuroglobin is highly conserved among vertebrates and is evolutionary related to the invertebrate nerve globins. In mouse and rat, neuroglobin is preferentially expressed in neuronal cells of the central and peripheral nervous systems, but also in some endocrine tissues. Neuroglobin is highly expressed in neurons of mammalian retina. | | Biochem/physiol Actions | Neuroglobin may play an essential role in oxygen homeostasis of neuronal cells. Neuroglobin is thought to protect neurons from hypoxic-ischemic injury as suggested by its increased expression under hypoxic conditions in- vitro as well as in focal cerebral ischemia in vivo. Neuronal survival after hypoxia decreased when neuroglobin expression is inhibited by antisense oligonucleotide and enhanced by neuroglobin overexpression. Its distribution correlates with the subcellular localization of mitochondria and with oxygen demands, possibly linking neuroglobin to cellular respiration. |
| | Anti-Ngb Preparation Products And Raw materials |
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