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| | 1-(1,3-Benzodioxol-5-ylmethyl)-6,7-dimethoxy-4-[(2S)-1-methylpyrrolidin-2-yl]isoquinoline Basic information |
| | 1-(1,3-Benzodioxol-5-ylmethyl)-6,7-dimethoxy-4-[(2S)-1-methylpyrrolidin-2-yl]isoquinoline Chemical Properties |
| Melting point | 107-110°C | | Boiling point | 552.5±50.0 °C(Predicted) | | density | 1.232±0.06 g/cm3(Predicted) | | pka | 8.81±0.40(Predicted) |
| | 1-(1,3-Benzodioxol-5-ylmethyl)-6,7-dimethoxy-4-[(2S)-1-methylpyrrolidin-2-yl]isoquinoline Usage And Synthesis |
| Description | This newly discovered alkaloid has been isolated from Papaver macrostomum.
It crystallizes as colourless rods from C6H6 and is laevorotatory with a specific
rotation of [α]25D - 51 ° ± 3° (c 0.892, CHCI3). It gives a complex ultraviolet
spectrum in EtOH with absorption maxima at 241,288,317 and 332 nm with
shoulders at 246, 276 and 292 nm. In the presence of dilute acid, these
absorption maxima appear at 259, 290 and 319 nm with a shoulder at 333 nm.
Macrostomine is found in the non-quaternary fraction of the alkaloidal extract.
It gives a negative Cotton effect which leads to the assumption that the
configuration is S. The alkaloid forms a crystalline methiodide with m.p.
220-230°C as slender needles when crystallized from EtOH. The structure given
has been determined from chemical and spectroscopic data. | | References | Minatsakanyan et ai., Tetrahedron Lett., 851 (1974) |
| | 1-(1,3-Benzodioxol-5-ylmethyl)-6,7-dimethoxy-4-[(2S)-1-methylpyrrolidin-2-yl]isoquinoline Preparation Products And Raw materials |
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