ALVAMELINE
| 中文名称 | ALVAMELINE |
|---|---|
| 中文同义词 | 阿伐美林;化合物 T14197 |
| 英文名称 | ALVAMELINE |
| 英文同义词 | ALVAMELINE;3-(2-Ethyl-2H-tetrazol-5-yl)-1,2,5,6-tetrahydro-1-methylpyridine;Lu 25-109;2-Ethyl-5-(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)-2H-tetrazole tartrate;3-(2-Ethyl-2H-tetrazol-5-yl)-1,2,5,6-tetrahydro-1-methyl-pyridine tartrate;5-(2-Ethyl-2H-tetrazol-5-yl)-1,2,3,6-tetrahydro-1-methylpyridine tartrate;Pyridine, 3-(2-ethyl-2H-tetrazol-5-yl)-1,2,5,6-tetrahydro-1-methyl- |
| CAS号 | 120241-31-8 |
| 分子式 | C9H15N5 |
| 分子量 | 193.25 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 120241-31-8.mol |
| 结构式 |  |
ALVAMELINE 性质
| 沸点 | 342.1±52.0 °C(Predicted) |
|---|---|
| 密度 | 1.25±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 7.29±0.40(Predicted) |
Alvameline is metabolized by human liver microsomes to Lu 31-126 mainly by CYP2D6; to Lu 29-297 and Lu 25-077 mainly by CYP1A2, CYP2A6, CYP2C19, and CYP3A4; and to Lu 32-181 by CYP1A2 and possibly by CYP2C19. One metabolite, Lu 32-181, could be reduced back to alvameline, a reaction not inhibited by the applied cytochrome P-450 inhibitors.
Alvameline competitively and effectively antagonizes carbachol-induced contractions and contractions induced by electrical field stimulation in human detrusor muscle. Alvameline produces a concentration-dependent rightward shift of the concentration-response curves for carbachol in both human and pig detrusor, the pK b values being 6.2 and 5.8. Contractions induced by electrical field stimulation in human detrusor are almost completely inhibited by 100 μM alvameline. In contrast, electrical field stimulation-induced contractions in pig detrusor are less sensitive to alvameline, resulting in a final inhibition of 32% with the highest concentration used (100 μM). Alvameline has been shown to improve cognitive function following traumatic brain injury in rats. Alvameline treated rats causes a 13% and 5% decrease in the medial septal nucleus, a 48 and 23% decrease in the vertical limb nucleus of the diagonal band, and a 51 and 28% decrease in the nucleus basalis magnocellularis, respectively.