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| Product Name: | AZ-23 | | Synonyms: | (S)-5-chloro-N2-(1-(5-fluoropyridin-2-yl)ethyl)-N4-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine;AZ-23;5-Chloro-N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-N'-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine;AZ23; AZ-23;2,4-Pyrimidinediamine, 5-chloro-N2-[(1S)-1-(5-fluoro-2-pyridinyl)ethyl]-N4-[5-(1-methylethoxy)-1H-pyrazol-3-yl]-;Tropomyosin related kinase receptor,Inhibitor,inhibit,AZ-23,Trk Receptor | | CAS: | 915720-21-7 | | MF: | C17H19ClFN7O | | MW: | 391.8304632 | | EINECS: | | | Product Categories: | | | Mol File: | 915720-21-7.mol |  |
| | AZ-23 Chemical Properties |
| Boiling point | 596.1±60.0 °C(Predicted) | | density | 1.411 | | storage temp. | Store at -20°C | | solubility | DMSO:125.0(Max Conc. mg/mL);319.02(Max Conc. mM) | | pka | 12.37±0.10(Predicted) | | form | Solid | | color | White to off-white |
| | AZ-23 Usage And Synthesis |
| Uses | 5-Chloro-N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-N'-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZ-23) is a potent and selective tyrosine kinase inhibitor which may be used in the therapeutic treatment of cancers. | | Biological Activity | AZ-23 is an ATP-competitive, orally active Trk kinase A/B/C inhibitor with IC50 values of 2 nM (TrkA), 8 nM (TrkB), 24 nM (FGFR1), 52 nM (Flt3) , 55 nM (Ret), 84 nM (MuSk), 99 nM (Lck). | | in vitro | AZ-23 potently and selectivity inhibits Trk phosphorylation in cells. AZ-23 potently inhibits Trk-mediated survival (EC 50 of 2 nM). AZ-23 Inhibits Trk-Dependent Survival in MCF10ATrkA-Δ and TF-1 Cell Lines. | | in vivo | AZ-23 shows in vivo TrkA kinase inhibition and efficacy in mice following oral administration in a TrkA-driven allograft model and significant tumor growth inhibition in a Trk-expressing xenograft model of neuroblastoma . | | target | | TrkA 2 nM (IC 50 ) | TrkB 8 nM (IC 50 ) | |
| | AZ-23 Preparation Products And Raw materials |
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