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| ICA 069673 Basic information |
Product Name: | ICA 069673 | Synonyms: | ICA 069673;N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide;ICA069673;ICA-069673;Benzamide, N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-;ICA-069673 >=98% (HPLC);Potassium Channel,ICA 069673,ICA-069673,KcsA,inhibit,Inhibitor;N-(2-Chloropyrimidin-5-yl)-3,4-difluorobenzamide | CAS: | 582323-16-8 | MF: | C11H6ClF2N3O | MW: | 269.63 | EINECS: | | Product Categories: | Selective KCNQ2/Q3 potassium channel opener. | Mol File: | 582323-16-8.mol | |
| ICA 069673 Chemical Properties |
Boiling point | 358.9±37.0 °C(Predicted) | density | 1.539±0.06 g/cm3(Predicted) | storage temp. | Sealed in dry,Room Temperature | solubility | DNF:30.0(Max Conc. mg/mL);111.26(Max Conc. mM) DMSO:36.24(Max Conc. mg/mL);134.4(Max Conc. mM) Ethanol:30.25(Max Conc. mg/mL);112.18(Max Conc. mM) | form | Powder | pka | 9.47±0.70(Predicted) | color | White to off-white |
| ICA 069673 Usage And Synthesis |
Description | ICA 069673 is a heteromeric Kv7 channel activator. It is selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50s = 0.69 and 14.3 μM, respectively) and also activates Kv7.4, Kv7.5, and heteromeric Kv7.4/7.5 channels in a dose-dependent manner. ICA 069673 has no activity against hERG, Nav1.5, and Kv7.1 cardiac ion channels (IC50s = >30 μM). Oral administration of ICA 069673 increases latency to first tonic-clonic seizure in the rat maximal electroshock and pentylentetrazol-induced seizure models (ED50s = 1.5 and <1 mg/kg, respectively). Formulations containing ICA 069673 are under clinical investigation for the treatment of epilepsy. | storage | Room temperature |
| ICA 069673 Preparation Products And Raw materials |
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