| Company Name: |
EMMX Biotechnology LLC
|
| Tel: |
888-539-0666 |
| Email: |
info@emmx.com |
| Products Intro: |
Product Name:Ro 01-6128
CAS:302841-86-7
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| Company Name: |
MQ (shanghai) Pharmaceuticals Co., Ltd.
|
| Tel: |
13761635123 |
| Email: |
1014988033@qq.com |
| Products Intro: |
Product Name:Ethyl (2,2-diphenylacetyl)carbamate
CAS:302841-86-7
Purity:＞95% Package:1G，5G
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| Company Name: |
MedBioPharmaceutical Technology Inc
|
| Tel: |
021-69568360 18916172912 |
| Email: |
order@med-bio.cn |
| Products Intro: |
Product Name:Ro 01-6128
CAS:302841-86-7
Purity:98% Package:50mg; 10mg Remarks:Medbio
|
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| | Ro 01-6128 Basic information |
| Product Name: | Ro 01-6128 | | Synonyms: | Ro 01-6128;ILSZPWZFQHSKLW-UHFFFAOYSA-N;(Diphenylacetyl)-carbamic acid ethy ester;ethyl N-[2,2-di(phenyl)acetyl]carbamate;Ro 01 6128,Ro 016128;Carbamic acid, N-(2,2-diphenylacetyl)-, ethyl ester;Ethyl (2,2-diphenylacetyl)carbamate | | CAS: | 302841-86-7 | | MF: | C17H17NO3 | | MW: | 283.32 | | EINECS: | | | Product Categories: | | | Mol File: | 302841-86-7.mol |  |
| | Ro 01-6128 Chemical Properties |
| density | 1.156±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol | | form | Powder | | pka | 7.97±0.46(Predicted) | | color | White to light brown |
| | Ro 01-6128 Usage And Synthesis |
| Description | Glutamate, the major excitatory neurotransmitter in the CNS, activates eight known subtypes of metabotropic glutamate receptors (mGluRs). Highly selective modulators designed to act at allosteric sites on certain mGluR subtypes are being developed to preferentially regulate subtype-specific, glutamate-induced receptor activation. Ro 01-6128 is a positive allosteric modulator of mGluR1 that can potentiate glutamate-induced calcium release at rat mGluR1a with an EC50 value of 104 nM. Ro 01-6128 activates ERK1/2 phosphorylation in the absence of exogenously added glutamate with an EC50 value of 248 nM and potentiates glutamate-induced cAMP production with an EC50 value of 21.5 μM. | | Uses | Ro 01-6128 is an allosteric mGluR-1 activator. |
| | Ro 01-6128 Preparation Products And Raw materials |
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