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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627 |
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info@efebio.com |
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Product Name:4-Quinolone-3-Carboxamide Furan CB2 Agonist
CAS:1314230-75-5
Purity:98% Package:1mg;5mg;10mg
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
| Products Intro: |
Product Name:4-Quinolone-3-Carboxamide Furan CB2 Agonist
CAS:1314230-75-5
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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Nantong Hi-Future Biotechnology Co., Ltd
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18051384581 |
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sales@chemhifuture.com |
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Product Name:CB2 receptor agonist 2
CAS:1314230-75-5
Purity:98%+ HPLC Package:10mg，100mg，500mg，1g，2g，5g，10g，more
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| Company Name: |
TargetMol Chemicals Inc.
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4008200310 |
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marketing@tsbiochem.com |
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Product Name:CB2 receptor agonist 2
CAS:1314230-75-5
Purity:98.07% Package:1 mg;10 mg;2 mg;25 mg;5 mg;50 mg
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| Company Name: |
ApexBio Technology
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+ 1-832-696-8203 |
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sales@apexbt.com |
| Products Intro: |
Product Name:4-Quinolone-3-Carboxamide Furan CB2 Agonist
CAS:1314230-75-5
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| | 4-Quinolone-3-Carboxamide Furan CB2 Agonist Basic information |
| Product Name: | 4-Quinolone-3-Carboxamide Furan CB2 Agonist | | Synonyms: | 4-Quinolone-3-Carboxamide Furan CB2 Agonist;N-(1-adamantyl)-6-(furan-2-yl)-8-methoxy-4-oxo-1-pentylquinoline-3-carboxamide;3-Quinolinecarboxamide, 6-(2-furanyl)-1,4-dihydro-8-methoxy-4-oxo-1-pentyl-N-tricyclo[3.3.1.13,7]dec-1-yl-;CB2 receptor agonist 2 | | CAS: | 1314230-75-5 | | MF: | C30H36N2O4 | | MW: | 488.62 | | EINECS: | | | Product Categories: | | | Mol File: | 1314230-75-5.mol |  |
| | 4-Quinolone-3-Carboxamide Furan CB2 Agonist Chemical Properties |
| storage temp. | Store at -20°C | | solubility | ≤30mg/ml in ethanol;3mg/ml in DMSO;3mg/ml in dimethyl formamide | | form | crystalline solid | | color | White to light yellow |
| | 4-Quinolone-3-Carboxamide Furan CB2 Agonist Usage And Synthesis |
| Biological Activity | ki: 8.5 nm4-quinolone-3-carboxamide furan cb2 agonist is a high-affinity ligand of cb2.the endocannabinoid system consists of endogenous cannabinoids (endocannabinoids), cannabinoid receptors (primarily cb1 and cb2), and the enzymes that synthesize and degrade endocannabinoids. | | in vitro | previous study found that 4-quinolone-3-carboxamide furan cb2 agonist (4g) was devoid of any potential “indirect” agonist activity at cannabinoid receptors, exerted by prolonging the lifespan of endocannabinoids because 4g at up to a 10 μm concentration did not inhibit anandamide or 2-ag degradation by faah or magl, respectively. in cytotosicity study, 4g was tested at 1 μm and the results showed that it exhibited very low or no cytotoxicity, the cell viability being above 95% after a 72 h treatment [1]. | | in vivo | in animal study, 4g was found to have antinociceptive activity in the formalin test in mice. moreover, 4g was very potent with maximal effect being reached at the 1 mg/kg dose and efficacious also on the first phase of the nocifensive response. the effect of 4g could be strongly reduced by the addition of am630, a cb2-selective antagonist/inverse agonist, therefore demonstrating that 4g might act as a potent and selective cb2 agonist [1]. | | references | [1] s. pasquini, m. de rosa, v. pedani, et al. investigations on the 4-quinolone-3-carboxylic acid motif. 4. identification of new potent and selective ligands for the cannabinoid type 2 receptor with diverse substitution patterns and antihyperalgesic effects in mice. journal of medicinal chemistry 54, 5444-5453 (2011). |
| | 4-Quinolone-3-Carboxamide Furan CB2 Agonist Preparation Products And Raw materials |
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