| Company Name: |
Alfa Chemistry
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1-516-6625404 |
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| Products Intro: |
Product Name:8,11,14-Eicosatriynoic acid
CAS:34262-64-1
Purity:98%+ Package:1g;10g;100g;1KG;5KG
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| Company Name: |
MedBioPharmaceutical Technology Inc
|
| Tel: |
021-69568360 18916172912 |
| Email: |
order@med-bio.cn |
| Products Intro: |
Product Name:8,11,14-Eicosatriynoic Acid
CAS:34262-64-1
Purity:98% Package:1mg; 5mg; 10mg Remarks:Medbio
|
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| | 8,11,14-Eicosatriynoic Acid Basic information |
| | 8,11,14-Eicosatriynoic Acid Chemical Properties |
| Boiling point | 469.6±40.0 °C(Predicted) | | density | 0.990±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≤100mg/ml in ethanol;100mg/ml in DMSO;100mg/ml in dimethyl formamide | | form | crystalline solid | | pka | 4.76±0.10(Predicted) |
| | 8,11,14-Eicosatriynoic Acid Usage And Synthesis |
| Definition | ChEBI: 8,11,14,18-Eicosatetraynoic acid is a long-chain fatty acid. | | Biological Activity | 8,11,14-eicosatriynoic acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid induced platelet aggregation, blocks human 12-lipoxygenase (12-lo), cyclooxygenase (cox), and 5-lipoxygenase (5-lo) with ic50 values of 0.46 μm, 14 μm, and 25 μm, respectively. also, it inhibits the actions of slow-reacting substance of anaphylaxis with an ic50 value of 10 μm [1,2].lipoxygenases are found widely in fungi, plants, and animals in high levels. 12-lo is involved in a number of significant disease states and may play a role in oxidative glutamate toxicity. cox enzymes play elaborate roles in human physiology and pathology, involving neuronal, immune, renal, cardiovascular, gastrointestinal, and reproductive systems. cox enzymes are blocked by aspirin and a wide variety of other non-steroidal anti-inflammatory drugs, which makes them important clinically [3]. 5-lo is involved in cancer pathobiology. it is expressed by a variety of cancer cells including colon, lung, breast, and prostate and promotes cancer cell growth and neo-angiogenesis. | | references | [1]. goetz, j., sprecher, h., cornwell, d., & panganamala, r. inhibition of prostaglandin biosynthesis by triynoic acids. prostaglandins. 1976; 12(2): 187-192.
[2]. sun, f., mcguire, j., morton, d., pike, j., sprecher, h., & kunau, w. inhibition of platelet arachidonic acid 12-lipoxygenase by acetylenic acid compounds. prostaglandins. 1981; 21(2): 333-343.
[3]. fitzpatrick, f. cyclooxygenase enzymes: regulation and function. current pharmaceutical design. 2004; 10(6): 577-588. |
| | 8,11,14-Eicosatriynoic Acid Preparation Products And Raw materials |
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