| Company Name: |
Chemsky (shanghai) International Co.,Ltd
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| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:ENMD 547-d8;6-AMino-1-[4-(3-Methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone-d8 HydrobroMide; 1-(6-AMino-1-oxohexyl)-4-(3-Methyl-1-oxobutyl)piperazine-d8 MonohydrobroMide
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
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| | 1-(6-AMino-1-oxohexyl)-4-(3-Methyl-1-oxobutyl)piperazine-d8 MonohydrobroMide Basic information |
| | 1-(6-AMino-1-oxohexyl)-4-(3-Methyl-1-oxobutyl)piperazine-d8 MonohydrobroMide Chemical Properties |
| | 1-(6-AMino-1-oxohexyl)-4-(3-Methyl-1-oxobutyl)piperazine-d8 MonohydrobroMide Usage And Synthesis |
| Uses | 1-(6-AMino-1-oxohexyl)-4-(3-Methyl-1-oxobutyl)piperazine-d8 Monohydrobromide: Labelled ENMD 547, a selective PAR-2 antagonist. Dose dependently inhibits calcium signaling in Lewis lung carcinoma cells stimulated with a soluble peptide PAR-2 agonist or trypsin, but not with a so luble PAR-1 agonist. Does not inhibit platelet aggregation stimulated by thrombin suggesting that it does not inhibit PAR-3 or PAR-4 signaling. Reduces TNF-a and IL-1β production from rheumatoid arthr itis synovial primary cell culture and reduces joint swelling in a carageenan/kaloin-injected mouse model. |
| | 1-(6-AMino-1-oxohexyl)-4-(3-Methyl-1-oxobutyl)piperazine-d8 MonohydrobroMide Preparation Products And Raw materials |
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