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| | 4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl- Basic information |
| Product Name: | 4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl- | | Synonyms: | 4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl-;TGR5;3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl-4-IsoxazolecarboxaMide;TGR5 Receptor Agonist;3-(2-CHLOROPHENYL)-N-(4-CHLOROPHENYL)-N,5-DIMETHYLISOXAZOLE-4-CARBOXAMIDE;3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-4-isoxazolecarboxamide TGR5;TGR5 4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl-;TGR5 Receptor Agonist, >=98% | | CAS: | 1197300-24-5 | | MF: | C18H14Cl2N2O2 | | MW: | 361.22 | | EINECS: | 200-256-5 | | Product Categories: | Inhibitors | | Mol File: | 1197300-24-5.mol |  |
| | 4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl- Chemical Properties |
| Boiling point | 541.8±50.0 °C(Predicted) | | density | 1.346±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml; Ethanol: 30 mg/ml | | form | A crystalline solid | | pka | -0.52±0.50(Predicted) | | color | White to off-white |
| | 4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl- Usage And Synthesis |
| Description | TGR5 receptor agonist is an agonist of the bile acid G protein-coupled receptor TGR5 (EC50s = 31.6-158.5 nM in cell-based assays). It stimulates cAMP formation in HEK293 cells expressing TGR5 (EC50 = 2.3 pM). TGR5 receptor agonist (1 mg/kg) increases glucagon-like peptide 1 (GLP-1) secretion and decreases glucose levels in the hepatic portal vein in dogs when administered in combination with glucose. It also inhibits the cytochrome P450 (CYP) isozymes CYP2C19 and CYP3A4 (IC50s = 316.2 and 1,259 nM, respectively). |
| | 4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl- Preparation Products And Raw materials |
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