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AP1903

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AP1903 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:Fosravuconazole L-lysine ethanolate
CAS:195514-63-7
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G
Company Name: BOC Sciences
Tel: +1-631-485-4226
Email: inquiry@bocsci.com
Products Intro: Product Name:AP1903
CAS:195514-63-7
Purity:0.98 Package:50mg Remarks:BOC Sciences also provides custom synthesis services for AP1903.
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:Rimiducid
CAS:195514-63-7
Purity:99.03% Package:1mg;138USD|2mg;197USD|5mg;317USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 +8613203830695
Email: laboratory@coreychem.com
Products Intro: Product Name:AP1903
CAS:195514-63-7
Purity:95%-99% crystal Liu Package:1KG;0.01USD
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
Email: sales@hzclap.com
Products Intro: Product Name:AP1903
CAS:195514-63-7
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good

AP1903 manufacturers

  • Rimiducid
  • Rimiducid pictures
  • $138.00 / 1mg
  • 2024-11-19
  • CAS:195514-63-7
  • Min. Order:
  • Purity: 99.03%
  • Supply Ability: 10g
  • Rimiducid
  • Rimiducid pictures
  • $138.00 / 1mg
  • 2024-11-19
  • CAS:195514-63-7
  • Min. Order:
  • Purity: 99.03%
  • Supply Ability: 10g
AP1903 Basic information
Product Name:AP1903
Synonyms:AP1903;Rimiducid(AP1903);AP1903;RIMIDUCID;AP-1903;AP1903 (Rimiducid;CS-1237;RIMIDUCID;AP-1903;AP 1903;2-Piperidinecarboxylic acid, 1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-, 2,2'-[1,2-ethanediylbis[imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene[(1R)-3-(3,4-dimethoxyphenyl)propylidene]]] ester, (2S,2'S)-;(1R,1'R)-((((Ethane-1,2-diylbis(azanediyl))bis(2-oxoethane-2,1-diyl))bis(oxy))bis(3,1-phenylene))bis(3-(3,4-dimethoxyphenyl)propane-1,1-diyl) (2S,2'S)-bis(1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate)
CAS:195514-63-7
MF:C78H98N4O20
MW:1411.63
EINECS:604-604-1
Product Categories:
Mol File:195514-63-7.mol
AP1903 Structure
AP1903 Chemical Properties
Boiling point 1307.5±65.0 °C(Predicted)
density 1?+-.0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO:97.05(Max Conc. mg/mL);68.75(Max Conc. mM)
Ethanol:120.58(Max Conc. mg/mL);85.42(Max Conc. mM)
form A solid
pka13.70±0.46(Predicted)
color White to light yellow
Safety Information
MSDS Information
AP1903 Usage And Synthesis
Biological ActivityAP1903 (Rimiducid) is a dimerizing agent that acts by cross-linking the FKBP domain, initiating Fas signaling and causing apoptosis.It dimerizes the Caspase 9 suicide switch and rapidly induces apoptosis.
in vitro

The human fibrosarcoma line HT1080 is engineered to express stably a fusion protein comprising a myristoylation sequence, two copies of F36V-FKBP, and the human first apoptosis signal (Fas) intracellular domain. Rimiducid (AP1903) elicits potent and dose-dependent apoptotic death of these engineered cells in culture, with an EC 50 of ≈0.1 nM. Maximal killing occurred in the presence of 3 to 10 nM Rimiducid (AP1903), and the IC 50 is approximately 0.2 nM. LV′VFas-transduced T lymphocytes expressing high levels of CD25 (top panel) are eliminated by with 66%±7.5% (n=10) efficiency. When cells are examined after CD25 expression returned to basal levels, 63%±4.7% (n=9) killing is observed after Rimiducid treatment.

in vivo

AP1903 elicits a dose-dependent decrease in serum human GH levels, with a half-maximal effective dose of 0.4±0.1 mg /kg.

target

EC50: 0.1 nM (FKBP, in HT1080 cells)
Fas receptor

storageStore at -20°C
AP1903 Preparation Products And Raw materials
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