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| | ATH 686 Basic information |
| Product Name: | ATH 686 | | Synonyms: | ATH 686;1-[4-(2-AMinopyriMidin-4-yloxy)phenyl]-3-[4-[(4-ethylpiperazin-1-yl)Methyl]-3-trifluoroMethylphenyl]urea;ATH686,inhibit,CD135,Inhibitor,Apoptosis,ATH-686,ATP-competitive,FLT3,antileukemic,Fms like tyrosine kinase 3,autophosphorylation,Cluster of differentiation antigen 135;Urea, N-[4-[(2-amino-4-pyrimidinyl)oxy]phenyl]-N'-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]- | | CAS: | 853299-52-2 | | MF: | C25H28F3N7O2 | | MW: | 515.53 | | EINECS: | | | Product Categories: | | | Mol File: | 853299-52-2.mol |  |
| | ATH 686 Chemical Properties |
| density | 1.364±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 250 mg/mL (484.94 mM; Need ultrasonic) | | pka | 13.32±0.70(Predicted) | | form | Solid | | color | White to light brown |
| | ATH 686 Usage And Synthesis |
| Biological Activity | ATH686 is a potent, selective and ATP-competitive FLT3 inhibitor. ATH686 target mutant FLT3 protein kinase activity and inhibit the proliferation of cells harboring FLT3 mutants via induction of apoptosis and cell cycle inhibition. ATH686 has antileukemic effects[1].
ATH686 (1-100 μM; 3 days) potently inhibits cell proliferation (IC50 around 0.001 μM) via induction of apoptosis in FLT3-ITD-Ba/F3 cells and D835Y-Ba/F3 cells[1]. ATH686 (10 nM; for 15 minutes) inhibits autophosphorylation of mutant FLT3 in FLT3-ITD-Ba/F3 cells[1]. | | References | [1]. Ellen Weisberg, et al. Antileukemic Effects of Novel First- and Second-Generation FLT3 Inhibitors: Structure-Affinity Comparison. Genes Cancer. 2010 Oct;1(10):1021-32. |
| | ATH 686 Preparation Products And Raw materials |
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