TD-198946
中文名称 | TD-198946 |
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中文同义词 | TD-198946 (1-METHYL-8-[4-(2-QUINOLINYLMETHOXY)PHENOXY]-4,5-DIHYDRO-1H-THIENO [3,4-G]INDAZOLE-6-CARBOXAMIDE);化合物TD198946;1-甲基-8-(4-(喹啉-2-甲氧基)苯氧基)-4,5-二氢-1H-噻吩并[3,4-G]吲唑-6-甲酰胺;4,5-二氢-1-甲基-8-[4-(2-喹啉基甲氧基)苯氧基]-1H-噻吩并[3,4-G]吲唑-6-甲酰胺 |
英文名称 | TD-198946 |
英文同义词 | TD-198946;1-(3-PYRIDINYLMETHYL)-4-PIPERIDINOL DIHYDROCHLORIDE;1-Methyl-8-[4-(2-quinolinylmethoxy)phenoxy]-4,5-dihydro-1H-thieno [3,4-g]indazole-6-carboxamide;4,5-dihydro-1-methyl-8-[4-(2-quinolinylmethoxy)phenoxy]-1H-thieno[3,4-g]indazole-6-carboxamide;TD198946;TD 198946;TD-198946, >98%;TD-198946 (1-methyl-8-[4-(2-quinolinylmethoxy)phenoxy]-4,5-dihydro-1h-thieno [3,4-g]indazole-6-carboxamide);1H-Thieno[3,4-g]indazole-6-carboxamide, 4,5-dihydro-1-methyl-8-[4-(2-quinolinylmethoxy)phenoxy]- |
CAS号 | 364762-86-7 |
分子式 | C27H22N4O3S |
分子量 | 482.55 |
EINECS号 | |
相关类别 | |
Mol文件 | 364762-86-7.mol |
结构式 | ![]() |
TD-198946 性质
沸点 | 699.5±55.0 °C(Predicted) |
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密度 | 1.43±0.1 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 溶于二甲基亚砜 |
酸度系数(pKa) | 15.87±0.20(Predicted) |
形态 | 固体 |
颜色 | 白色至浅黄色 |
TD-198946 is a potent chondrogenic agent. TD-198946 strongly induces chondrogenic differentiation without promoting hypertrophy in cell and metatarsal organ cultures. TD-198946 induces stronger Col2a1 promoter activity than insulin in ATDC5 cells. In C3H10T1/2 cells, ATDC5 cells and primary mouse chondrocytes, TD-198946 dose-dependently stimulates endogenous expression of the chondrocyte markers Col2a1 and Acan , with maximum effects around 1-10 μM.
When administered directly into the joint space, TD-198946 successfully prevents and repaires degeneration of the articular cartilage. TD-198946 exerts its effect through the regulation of Runx1 expression, which is downregulated in both mouse and human OA cartilage compared with normal tissue. TD-198946 has disease-modifying effects on progressed osteoarthritis. TD-198946 may prevent the progression of osteoarthritis by acting on the remaining chondrocytes rather than repairing damaged cartilage, it may be most effective as a therapeutic during the early or middle stages of osteoarthritis, before the articular cartilage is fully eroded. Cartilaginous cell-sheets are generated by culturing mouse and canine costal chondrocytes and human mesenchymal stem cells with TD-198946 on temperature-responsive dishes. The transplanted cell-sheets are then successfully used to promote the reconstruction of permanent cartilage, with no evidence of chondrocyte hypertrophy in the knee articular cartilage defects created in mice and canines.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-15642 | TD-198946 TD-198946 | 364762-86-7 | 1mg | 1142元 |
2024/04/30 | HY-15642 | TD-198946 TD-198946 | 364762-86-7 | 5mg | 2200元 |