- RRX-001
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- $7.00 / 1KG
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2020-02-19
- CAS:925206-65-1
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100kg
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| | RRX-001 Basic information |
| Product Name: | RRX-001 | | Synonyms: | RRX-001;2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one;RRX 001;RRX001;[14C]-Rrx-001;2-Bromo-1-(3,3-dinitroazetidin-1-yl)ethanone;Ethanone, 2-bromo-1-(3,3-dinitro-1-azetidinyl)-;RRx-001 (ABDNAZ);ABDNAZ | | CAS: | 925206-65-1 | | MF: | C5H6BrN3O5 | | MW: | 268.02 | | EINECS: | | | Product Categories: | | | Mol File: | 925206-65-1.mol |  |
| | RRX-001 Chemical Properties |
| Boiling point | 473.0±45.0 °C(Predicted) | | density | 1.98±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 2 mg/ml | | form | A solid | | pka | -2.07±0.20(Predicted) | | color | White to off-white |
| | RRX-001 Usage And Synthesis |
| Biological Activity | RRx-001 is a novel epigenetic modulator with potential radiosensitizing activity. In human tumor cells, it inhibits glucose 6-phosphate dehydrogenase (G6PD), binds to hemoglobin and drives RBC-mediated redox reactions under hypoxia.It can trigger apoptosis and has antitumor activity. | | in vitro | RRx-001 exerts its antiproliferative effect by interfering with glucose 6 phosphate dehydrogenase (G6PD), a key enzyme in the pentose phosphate pathway. RRx-001 induces p53 and PARP-1 through ROS/RNS generation. It exerts its anticancer activity by interfering and disrupting 3 crucial metabolic demands in rapidly proliferating cells: bioenergetics, macromolecular biosynthesis and manipulation of cellular cytoplasmic redox homeostasis.RRx-001 also mediates the nuclear translocation of Nrf2 and the expression of its downstream HO-1 and NQO1 in tumor cells. | | in vivo | RRx-001 has a short-term blood flow redistribution effect in tumors enriched in pericytes and α-SMA vessels.It was well tolerated without dose-limiting toxic side effects. In mice, it not only promoted nuclear transport of Nrf2, but also upregulated the expression of endogenous Nrf2 in SCC VII tumors. | | target | | Target | Value | G6PD
() | | Nrf2-ARE |
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| | RRX-001 Preparation Products And Raw materials |
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