RAS-2410 hydrochloride manufacturers
- RAS-2410 hydrochloride
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- $0.00 / 1gram
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2022-02-19
- CAS:1187075-34-8
- Min. Order: 1gram
- Purity: 99%
- Supply Ability: 10kg
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| RAS-2410 hydrochloride Basic information |
Product Name: | RAS-2410 hydrochloride | Synonyms: | 4SC-201 hydrochloride;RAS 2410 hydrochloride;RAS2410 hydrochloride;RAS-2410 hydrochloride;ResMinostat (hydrochloride);(2E)-3-[1-[[4-[(Dimethylamino)methyl]phenyl]sulfonyl]-1H-pyrrol-3-yl]-N-hydroxy-2-propenamide hydrochloride (1:1);Resminostat HCl;RAS2410; 4SC-201; RAS 2410; RAS-2410;4SC201;4SC 201 | CAS: | 1187075-34-8 | MF: | C16H20ClN3O4S | MW: | 385.8657 | EINECS: | | Product Categories: | APIs | Mol File: | 1187075-34-8.mol | |
| RAS-2410 hydrochloride Chemical Properties |
storage temp. | Store at -20°C | solubility | Soluble in DMSO | form | crystalline solid | color | White to off-white |
| RAS-2410 hydrochloride Usage And Synthesis |
Description | Resminostat is an orally bioavailable inhibitor of histone deacetylase 1 (HDAC1), HDAC3, and HDAC6 (IC50s = 43-72 nM), resulting in hyperacetylation of histone H4 in multiple myeloma cells. It abrogates cell growth and strongly induces apoptosis in multiple myeloma cells (IC50s = 2.5-3 μM). Resminostat displays synergistic effects when combined with melphalan and the proteasome inhibitors bortezomib and S-2209. It dose-dependently inhibits HDAC activity in vivo. | references | [1] mandl-weber s, meinel fg, jankowsky r, oduncu f, schmidmaier r, baumann p. the novel inhibitor of histone deacetylase resminostat (ras2410) inhibits proliferation and induces apoptosis in multiple myeloma (mm) cells. br j haematol. 2010 may;149(4):518-28. [2] brunetto at, ang je, lal r, olmos d, molife lr, kristeleit r, parker a, casamayor i, olaleye m, mais a, hauns b, strobel v, hentsch b, de bono js. first-in-human, pharmacokinetic and pharmacodynamic phase i study of resminostat, an oral histone deacetylase inhibitor, in patients with advanced solid tumors. clin cancer res. 2013 oct 1;19(19):5494-504. |
| RAS-2410 hydrochloride Preparation Products And Raw materials |
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